DOI: 10.14704/nq.2019.17.2.1992

Where Scizophrenia and Consciousness Intersect: Disorders of Consciousness in Schizophrenia

James Paul Pandarakalam

Abstract


The underlying biology of schizophrenia remains metaphorically an undiscovered black box and still requires a concentrated and rigorous extent of investigation. Consciousness is an enigma and an enigma cannot be defined, but it can be described. Consciousness itself requires better explanation in order to understand the symptoms of schizophrenia. Consciousness may have a
neurological origin, and the Penrose-Hameroff Orch OR theory may be helpful in elucidating only the mechanical quantum consciousness. The concept of quantum decoherence has been linked with psychopathology. A neuro-quantological approach has great potential for understanding the symptoms of schizophrenia as essentially disorders of consciousness. Auditory hallucinations may be acoustic holograms of parallel thinking. Non-clinical auditory hallucinations are not uncommon and pose an interpretational challenge. The symptoms of schizophrenia may encompass disorders of consciousness. Consciousness based studies of schizophrenic symptoms would necessitate formulations of new models of brain-mind-consciousness complex. A quantum leap is overdue in schizophrenia research itself both in the theoretical and experimental fields and the present paper is focussed on the former.

Keywords


auditory hallucination-consciousness, metacognition, microtubules, Orch OR, quantum factors, schizophrenia

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References


Anscombe Roderick, The Disorder of Consciousness in Schizophrenia, Schizophrenia Bulletin 1987; 13: 2.

Alfred Jay: Invisible bodies. Victoria, BC, Canada: Trafford Publishing, 2006.

Austin SF, Mors O, Nordentoft M, Hjorthøj CR, Secher RG, Hesse M, Hagen R, Spada M, Wells A. Schizophrenia and metacognition: an investigation of course of illness and metacognitive beliefs within a first episode psychosis. Cognitive therapy and research 2015; 39(1): 61-69.

Azuonye Obialo Ikechukwu, A difficult case: Diagnosis made by hallucinations. British Medical Journal 1997; 315: 1685.

Bandyopadhyay AG, Ghosh S, Sahu S. Evidence of massive global synchronization and the consciousness: Comment on “Consciousness in the universe: A review of the ’Orch OR’ theory” by Hameroff and Penrose. Biosens Bioelectron, 2013.

Bauer H. Henry. Experimental Replicability. Journal of Scientific Exploration 2018; 32(4): 721-722.

Bauer H. Henry. Science Is Not What You Think: How It Has Changed, Why We Can’t Trust It, How It Can Be Fixed. Jefferson NC 28640: McFarland Publishing, 2017.

Bayne Tim. The disunity of consciousness in psychiatric disorders.The Oxford handbook of philosophy and psychiatry. Oxford: Oxford University Press. 2013.

Bell V, Halligan PW, Ellis HD. Explaining delusions: a cognitive perspective. Trends in cognitive sciences 2006; 10(5): 219-226.

Benros ME, Pedersen MG, Rasmussen H, Eaton WW, Nordentoft M, Mortensen PB. A nationwide study on the risk of autoimmune diseases in individuals with a personal or a family history of schizophrenia and related psychosis. Am J Psychiatry 2014; 171: 218–264

Benitez-King G, Ramírez-Rodríguez G, Ortíz L, Meza I. The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia. Curr Drug Targets CNS Neurol Disord 2004; 3: 515-533.

Benitez-King G, Ramirez-Rodriguez G, Ortiz L. Altered Microtubule Associated Proteins in Schizophrenia. NeuroQuantology 2007; 5(1): 58-61.

Bleuler E. Dementia Praecox or the Group of Schizophrenias. New York: International Universities Press, 1950.

Bob P, Pec O, Mishara AL, Touskova T, Lysaker PH. Conscious brain, metacognition and schizophrenia. International journal of psychophysiology 2016; 105: 1-8.

Bošnjak Marija Pašić, Emina Horvat Velić, Luka Fotak, Hanna Pašić, Azijada Srkalović Imširagić, Davorka Milat, Helena Šarac, Sarah Bjedov, Željka Petelin Gadže: Many Faces of Deja Vu: A Narrative Review. Psychiatria Danubina 2018; 30: 21-25.

Busemeyer JR, Trueblood JS. Theoretical and empirical reasons for considering the application of quantum probability theory to human cognition. In Proceedings of the Quantum Cognition Meets TARK, Workshop, Groningen, The Netherlands, 2011.

Carter CJ. Schizophrenia: a pathogenetic autoimmune disease caused by viruses and pathogens and dependent on genes. Journal of pathogens. 2011; 2011: 128318.

Carter CJ. Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii. Schizophrenia bulletin 2008; 35(6): 1163-1182.

Choong C, Hunter MD, Woodruff PW. Auditory hallucinations in those populations that do not suffer from schizophrenia. Current Psychiatry Reports 2007; 9(3): 206-212.

Cocchi M, Tonello L, Gabrielli F. Quantum Paradigms of Psychopathology: From Consciousness to Neuroethics. Open Journal of Depression 2017; 6(01): 24-30.

Costas J, Suárez‐Rama JJ, Carrera N, Paz E, Páramo M, Agra S, Brenlla J, Ramos‐Rios R, Arrojo M. Role of DISC1 Interacting Proteins in Schizophrenia Risk from Genome‐Wide Analysis of Missense SNPs. Annals of human genetics 2013; 77(6): 504-512.

David AS. The Neuropsychology of auditory verbal hallucinations. In David A.& Cutting, J., eds. The neuropsychology of Schizophrenia., Hove’ Lawrence Erlbaum Association 1994; pp: 269-312.

David AS and Lucas P. Auditory verbal hallucinations’ phonological loop: a cognitive neuropsychological study. British J of Clinical Psychology 1993; 32: 431-441.

Dean CE. Antipsychotic-associated neuronal changes in the brain: Toxic, therapeutic, or irrelevant to the long-term outcome of schizophrenia? Prog Neuropsychopharmacol Biol Psychiatry 2006; 30(2): 174-189.

Dispeneza Joe. You are the Placebo. London: Hay House, 2014.

Eckenhoff RG. Direct Modulation of Microtubule Stability Contributes to Anthracene General Anaesthesia 2013. Obtenido de NIH: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671381/

Edelman G. Wider than the sky: The phenomenal gift of consciousness: New Haven, CN: Yale University Press, 2004.

Fenwick Peter and Elizabeth. The Truth in the Light. White Crow Books, 2012.

Fenwick Peter. The Art of Dying. London: Continuum, 2008.

Fontana David. Life beyond Death. London: Watkins Publishing, 2009.

Fuchs T. The temporal structure of intentionality and its disturbance in schizophrenia. Psychopathology 2007; 40: 229–235.

Fuchs T. Temporality and psychopathology. Phenomenol Cogn Sci 2013; 12: 75-104.

Fuster JM. Cortex and Mind—Unifying Cognition. Oxford, England: Oxford University Press, 2003.

Gallagher S. Philosophical conceptions of the self: implications for cognitive science. Trends Cogn Sci 2000; 4: 14–21.

Gauld Alan. Mediumship and Survival. London: Heinemann, 1982.

Ghaemi Nassir. Quantum Psychiatry: A new Paradigm? Neuroquantology 2010; 8: 49-50.

Ghosh S, Sahu S, Bandyopadhyay A. Evidence of massive global synchronization and the consciousness: comment on "Consciousness in the universe: a review of the 'Orch OR' theory" by Hameroff and Penrose. Phys Life Rev 2014; 11: 83-84; discussion 94-100.

Giersch A and Mishara AL. Is Schizophrenia a Disorder of Consciousness? Experimental and Phenomenological Support for Anomalous Unconscious Processing. Front. Psychol 2017; 8: 1659.

Globus G Gordon. Inner Speech and the Linguistic Sign: Toward Quantum Semiology. Neuroquantology 2011; 9(2): 243-254.

Globus G Gordon. Toward Quantum Psychiatry: Hallucinations, Thought Insertion and DSM. Neuroquantology 2010; 1: 1-12.

Globus G Gordon. The Postmodern Brain (Advances in Consciousness Research). Philadelphia: John Benjamin Publishing Company,1995.

Gloor P. The Temporal lobes and Limbic system. New York: Oxford university Press, 1997.

Gordana Rubesa, Lea Gudelj, Dolores Makovac. Immunological Characteristics of Schizophrenia. Psychiatria Danubina, 2018; 30(4): S180-S187

Goswami Amit. The Quantum Doctor. Charlottesville: Hampton Road Publishing Co, 2011

Grover Monendra. Quantum computation and Schizophrenia. International Journal of Computer Science & Engineering Technology (IJCSET). 2012; 1(3): 52-54.

Grover Monendra, Singh Rakesh, Kumar Rajesh, Trivedi AK. Mental Disorders and Fundamental Space Time Geometry at Planck Scale: A Hypothesis. International Journal of Advanced Biotechnology and Research 2013; 4(1): 920-924.

Hameroff SR. The brain is both neurocomputer and quantum computer. Cognitive Science 2007; 31(6): 1035-1045.

Hameroff SR. Consciousness, Microtubules & 'Orch OR'. A'Space-time Odyssey'. Journal of Consciousness Studies 2014; 21(3-4): 126-153.

Hameroff SR. Consciousness, neurobiology and quantum mechanics: The case for a connection. In The emerging physics of consciousness. Tuszynski, J.A. (Ed.), Springer, Berlin, Heidelberg, 2006; pp: 193-253.

Hameroff SR and Penrose R. Orchestrated reduction of quantum coherence in brain microtubules. A model for consciousness. Cambridge: MIT press,1996.

Hameroff SR. Stuart. Quantum Coherence in Microtubules> A neural basis for emergent consciousness? Journal of Consciousness Studies 1994; 1(1): 91-118.

Hamilton Max. Fish’s Clinical Psychopathology. Wright: Bristol, 1985.

Haug E, Øie M, Melle I, Andreassen OA, Raballo A, Bratlien U, Lien L, Møller P. The association between self-disorders and neurocognitive dysfunction in schizophrenia. Schizophrenia research 2012; 135(1-3): 79-83.

Husserl E. On the Phenomenology of the Consciousness of Internal Time (1893–1917). Brough JB, trans-ed. Dordrecht, Boston: Kluwer Academic Publishers 1991; 6.

Husserl E. Vorlesungen zur Phaenomenologie des inneren Zeitbewusstseins. Halle, Germany: Max Niemeyer Verlag, 1928.

Horowitz MJ, Adams JE, Rutkin BB. Visual imagery on brain stimulation. Archives of General Psychiatry 1968; 19(4): 469-486.

José M Villagrá. Consciousness Disorders in Schizophrenia: a Forgotten Land for Psychopathology. International Journal of Psychology and Psychological Therapy 2003; 3(2): 209-234.

Jahn G.Robert. The Challenge of Consciousness. The Journal of Scientific Exploration 2001; 15(1): 21-31.

Jeremy S Hyams and Clive W Lloyd. Microtubules: constructing cellular highways: Microtubules. Oxford: Wiley-Liss, 1994.

Jibu M and Yasu K. Quantum Brain Dynamics and Quantum Field Theory In Brain and being. Globus, G., Pribram K, Vitello G, eds, Amsterdam: John Benjamins, 2004.

Jung C. Psychology and the Occult. Princeton: Princeton University Press,1977.

Kennedy WG and Bugajska MD. Integrating Fast and Slow Cognitive Processes. In Proceedings of the Tenth International Conference on Cognitive Modelling, 121126.Philadelphia, PA., 2010.

Kaleağasıoğlu Ferda and Onur Rüştü. Quantum-Mechanical Interpretation of Metacognition

IJRRAS 2013; 16(4): 93-100.

Kelly Edward; Kelly Emily Williams; Crabtree Adam; Gauld Alan; Grosso Michael; Greyson Bruce; The Irreducible Mind. Rowman& Littlefield Inc: Lanham, 2007.

Keshavan MS, Nasrallah HA, Tandon R. Schizophrenia, “Just the Facts” 6. Moving ahead with the schizophrenia concept: from the elephant to the mouse. Schizophr Res 2011; 127: 3-13.

Koch C. The quest for consciousness: A neurobiological approach. Englewood: Roberts and Company, 2004.

Koch C and Crick F. The zombie within. Nature 2001; 411: 893.

Konradi C and Heckers S. Antipsychotic Drugs and Neuroplasticity: Insights into the Treatment and Neurobiology of Schizophrenia. Biological psychiatry 2001; 50(10): 729-742.

Landgdon R and Jones SR. Connaughton E, Fernyhough C.The phenomenology of inner speech: comparison of schizophrenia patients with auditory verbal hallucinations and healthy control. Psychol Med 2009; 39(4): 655-663.

Law AJ, Hutchinson LJ, Burnet PW, Harrison PJ. Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex. J Neurosci Res 2004; 76(3): 376-382.

Lepage M, Bodnar M, Bowie CR. Neurocognition: clinical and functional outcomes in schizophrenia. Can J Psychiatry 2014; 59: 5-12.

Johns LC, Kompus K, Connell M, Humpston C, Lincoln TM, Longden E, Preti A, Alderson-Day B, Badcock JC, Cella M, Fernyhough C. Auditory verbal hallucinations in persons with and without a need for care. Schizophrenia bulletin 2014; 40(Suppl_4): S255-S264.

Leon De Jose, Berman F Karen, Dalmau Josep. Serum IgG Antibodies Against the NR1 Subunit of the NMDA Receptor Not Detected in Schizophrenia (Letter to the Editor). American Journal of Psychiatry 2012; 169: 10.

Langdon R, Jones SR, Connaughton E, Fernyhough C. The phenomenology of inner speech: comparison of schizophrenia patients with auditory verbal hallucinations and healthy controls. Psychological medicine 2009; 39(4): 655-663.

Luan L, Xue R, Lu C, Cui A, Hou Y, Quan J, Xiang M, Wang X, Yuan W, Sun N, Meng D. Anti-serum with anti-autoantibody activity decreases autoantibody-positive B lymphocytes and type 1 diabetes of female NOD mice. Autoimmunity 2016; 49(1): 21-30.

MacDonald ML, Eaton ME, Dudman JT, Konradi C. Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biol Psychiatry 2005; 57(9): 1041-1051.

Martin B, Franck N, Cermolacce M, Coull JT and Giersch A. Minimal Self and Timing Disorders in Schizophrenia: A Case Report. Front Hum Neurosci 2018; 12: 132.

Mahl GF, Rothenberg A, Delgado JM, Hamlin H. Psychological responses in the human to intracerebral electrical stimulation. Psychosomatic Medicine. 1964.

Martin B, Wittmann M, Franck N, Cermolacce M, Berna F, Giersch A. Temporal structure of consciousness and minimal self in schizophrenia. Frontiers in psychology 2014; 5: 1175.

McGuire PK, David AS, Murray RM, Frackowiak RS, Frith CD, Wright I, Silbersweig DA. Abnormal monitoring of inner speech: a physiological basis for auditory hallucinations. The Lancet 1995 346(8975): 596-600.

McGinn Colin. Mysterious Flame: Conscious Minds in a Material world. New York: Basic Books, 1999.

Mindell Arnold. Quantum Mind, The Edge between Physics and Psychology. Portland: Lao Tse Press, 2000.

Mitchell ED and Staretz R. The Quantum Hologram and the Nature of Consciousness. J Cosmo 2011; 14.

Murray CJL, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge, Massachusetts: Harvard University Press, Harvard School of Public Health, 1996.

Northoff G. Brain and self- a neuro-philosophical account. Child Adolescence Psychiatry and Mental Health 2013; 7: 28.

Nelson B, Thompson A, Yung AR. Not all first‐episode psychosis is the same: preliminary evidence of greater basic self‐disturbance in schizophrenia spectrum cases. Early intervention in psychiatry 2013 7(2): 200-204.

Nayani TH, David AS. The auditory hallucination: a phenomenological survey. Psychological medicine 1996; 26(1): 177-189.

Nordgaard J, Arnfred SM, Handest P, Parnas J. The diagnostic status of first-rank symptoms. Schizophrenia bulletin 2007; 34(1): 137-154.

Owen GS, Cutting J, David AS. Are people with schizophrenia more logical than healthy volunteers?. The British Journal of Psychiatry 2007; 191(5): 453-454.

Parnas J. A disappearing heritage: the clinical core of schizophrenia. Schizophrenia bulletin. 2011 37(6): 1121-1130.

Parnas J, Møller P, Kircher T, Thalbitzer J, Jansson L, Handest P, Zahavi D. EASE: examination of anomalous self-experience. Psychopathology 2005; 38(5): 236-258.

Parnas J, Handest P, Saebye D, Jansson L. Anomalies of subjective experience in schizophrenia and psychotic bipolar illness. Acta Psychiatrica Scandinavica 2003; 108(2): 126-133.

Parnas J, Henriksen MG. Mysticism and schizophrenia: A phenomenological exploration of the structure of consciousness in the schizophrenia spectrum disorders. Consciousness and Cognition 2016 43: 75-88.

Pandarakalam JP. Is autoimmunity involved in the aetiology of schizophrenia?. Progress in Neurology and Psychiatry 2013; 17(1): 24-28.

Pandarakalam James Paul. The Autoimmune Etiological Factors of a Subset of Schizophrenia. BJMP 2015; 8: a831.

Pandarakalam James Paul. Auditory hallucinations and treatment challenges. Journal of Hospital Medicine 2014; 75: 217-222.

Pandarakalam James Paul. Auditory Hallucinations: Is the source of auditory hallucinations beyond the material brain? Paranormal Review 2015; 75: 22-25.

Pei Q, Burnet PJ, Zetterström TS. Changes in mRNA abundance of microtubule-associated proteins in the rat brain following electroconvulsive shock. Neuroreport 1998; 9: 391-394.

Penrose Rogers. The Emperor’s New Minds: Concerning computers, Minds, and The Laws of physics. Oxford: Oxford University Press,1989.

Penrose Rogers. Shadows of the mind: A search for the missing science of Consciousness. Oxford: oxford University Press, 1994.

Penrose R, Hameroff S. Consciousness and the Universe: Neuroscience, Quantum Space-Time Geometry and Orch OR Theory. Cambridge MA: Cosmology Science Publishers 2015, pp: 3-42.

Pereira Contzen. Cytoskeleton and Consciousness: An Evolutionary Based Review. NuroQuantology 2015; 13(2): 232-239

Rhawn Joseph. Dreams and Hallucinations, In consciousness and the Universe edited by Sir Roger Penrose, Stuart Hameroff & Subash Kak. pp: 518-550, Cambridge: Cosmology Science Publishers, 2011.

Rizig MA, McQuillin A, Ng A, Robinson M, Harrison A, Zvelebil M, et al. A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia. J Psychopharmacol 2012; 26: 1218-1230.

Sabu S, Ghos S, Hirala K, Fugita D, Bandoyopadhya A. A Multi-level Memory-switching Property of a Single Brain Microtubule. Apply Physics Lett 2013; 102: 123.

Sadock BJ and Sadock VA. Kaplan PR & Sadock’s comprehensive textbook of psychiatry – 9th ed., Lippincot Williams & Wilkins, Philadelphia, 2009

Sass A. Louis, Parnas Josef. Schizophrenia, Consciousness, and the Self. Schizophrenia Bulletin 2003; 29(3): 427-444.

Sharp SI, Hu Y, Weymer JF, Rizig M, McQuillin A, Hunt SP, Gurling HM. The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis. Psychiatric genetics 2013; 23(4): 153-162.

Smythies John. Brain and Consciousness: The ghost in the Machines. Journal of Scientific Exploration 2009; 23: 37-50.

Selesnick SA and Owen GS. Quantum-like logics and schizophrenia. Journal of Applied Logic 2012 10(1): 115-126.

Stein D and Ludik J. Neural networks and psychopathology: Connectionist models in practice and research. Cambridge: Cambridge University Press, 1998.

Stanghellini Giovanni. Disembodied Spirits and de-animated Bodies. Oxford: Oxford University Press, 2004.

Tuszzynaski JA and Woolf N. The path ahead. In: Tuszynski JA, editor. The emerging physics of consciousness. New York: Springer-Verlag, 2006.

Thyberg J, Axelsson JE, Hinek A. In vitro effects of chlorpromazine on microtubules and the Golgi complex in embryonic chick spinal ganglion cells: an electron microscopic study. Brain Res 1977; 137: 323-332.

Venkatasubramanian G and Debnath M. Neuro-immunological aberrations and cerebral asymmetry abnormalities in schizophrenia: select perspectives on pathogenesis. Clin Psychopharmacol Neurosci 2014; 12: 8-18.

Venkatasubramanian Ganessan. Understanding Schizophrenia as Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory. Clin Pharmacol Neurosci 2015; 13(1): 36-47.

Vogeley K and Kupke C. Disturbances of Time Consciousness from a Phenomenological and a Neuroscientific Perspective. Schizophrenia Bulletin 2007; 33(1): 157-165.

Zizzi P and Pregnolato M. Quantum logic of the unconscious and schizophrenia. Neuroquantology 2012, 10(3): 566-579.

Zizzi P. From Quantum Metalanguage to the Logic of Qubits. PhD Thesis, 2010. arXiv:1003.5976.

Wassenhove V Minding time in an a modal representational space. Philos Trans R Soc Lond B Biol Sci 2009; 364: 1815-1830.

Wittmann M. Moments in time. Front Integr Neurosci 2011; 5: 66.

Wassermann DG. Shadow Matter Body and Brain. Mandrake of Oxford: Oxford, 1993.

Wassermann DG. On a physical (materialistic) theory of psi phenomenon based on Shadow Matter Inquiry 1988; 31(2): 217-222.

Wiffen B and David A. Metacognition, mindreading, and insight in schizophrenia. Behavioural and Brain Sciences 2009; 32(2): 161-162.

Whitehead N. Process and Reality. Macmillan: New York, 1929.

Whitehead N. Adventure of Ideas. Macmillan: London, 1933.

Woolf NJ, Craddock TJ, Friesen DE, Tuszynski JA. Neuropsychiatric illness: a case for impaired neuroplasticity and possible quantum processing derailment in microtubules. NeuroQuantology 2009; 8(1): 13‐28.

Woolf NJ. Bionic microtubules: potential applications to multiple neurological and neuropsychiatric diseases. J Nanoneurosci 2009; 1: 85-94.


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