This paper shares the history of a researcher and his groundbreaking discoveries which have been discussed for a long time that started during a conversation with a dear friend, Kary Mullis. Using biological markers, the research involved the ability to classify and differentiate depressive disorders from apparent normality. This research crossed the path of Kary Mullis, one of the most important scientists of the modern era, who discovered the PCR (Polymerase Chain Reaction), which initiated a fundamental step in the research of genetics. This paper also examines the contributions of other important scientists and how they were led to hypothesize that the molecular circuit of consciousness could open “the possibility of penetrating beyond the present classical‐molecular theories about depression into the quantum domain of consciousness without throwing out what is already valuable in the standard paradigm,” as stated by Donald Mender in his groundbreaking paper titled “The Interactome Hypothesis of Depression.” Presently, the method utilized for the classification of depressive disorders has allowed, for the first time, the classification of the differentiation between bipolar disorder and major depression.

artificial neural network, bipolar disorder, classic consciousness, Kary Mullis, major depression, quantum consciousness