The placebo effect, long recognized as a robust contributor to clinical outcomes, has traditionally been explained in terms of expectation, conditioning, and meaning responses. Recent advances in open-label placebo (OLP) research demonstrate that placebo responses can be elicited without deception, reframing both ethical and mechanistic perspectives. Parallel to these developments, a growing body of theoretical work explores quantum and quantum-like frameworks as tools for modeling contextuality, non-classical probability structures, and consciousness-mediated effects relevant to placebo phenomena. This article introduces QUACEBO, a digital open-label placebo platform that integrates these perspectives by employing genuine quantum random number generator (QRNG) signals as dynamic visualizations to scaffold intention, ritual, and engagement.

Placebo effect; open-label placebo; digital placebo; quantum-like probability; QRNG; Process 1; Quantum Zeno Effect; QUACEBO; coherence; contextuality