Type II diabetes, is a type of diabetes that is characterized by hyperglycemia due to insulin resistance and/or relative lack of insulin due to obesity, lack of physical exercise or genetically determined. HbA1c level in diabetic patients provides valuable information about the changes occurring in the blood glucose level over the last three months. This increased glycation is thus involved in progression of diabetes and its complications. Also insulin resistance is a prominent feature of type II DM and contributes significantly to hyperglycemia. Serum concentration of Fetuin-A is directly correlatedwith insulin resistance and dyslipidemia because it inhibits the insulin-stimulated autophosphorylation of the insulin receptor. In several epidemiological studies, it is mentioned that insulin resistance (IR), metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are associated with higher level of serum Fetuin-A. These facts led us to think, to find out the correlation amongthe level of Fetuin A, HbA1c and insulin resistance in type II diabetic patients. This is the reason; we have correlated these parameters by using Karl Pearson’s Coefficient. In the present study we observed a significant correlation. It indicates that there is an influence of Fetuin-A on the glycemic control and insulin resistance, in type II diabetic subjects. It suggests that Fetuin-A can be used as Biochemical parameter to assess a glycemic control as well as Insulin Resistance in the diagnosis and prognosis of type 2 diabetes.

Type 2 DM, HbA1c, HOMA-IR and Fetuin-A