SYNTHESIS OF NEW 2,3- DISUBSTITUTED QUNINOXALINES FROM 2'-HYDROXY-4'- METHYL-5' BROMO -4- SUBSTITUTED CHALCONES

Volume 9 No 2 (2011)

Dr. Neelima s. Chauhan

DOI: 10.48047/nq.2011.9.2.260013

Abstract

2'- Hydroxy-4' methyl-5'-Bromo-4'- methoxy chalcone (la), 2'- hydroxy -4'-methyl-5'- bromo chalcone (lb), 2'- hydroxyl-4'methyl-5'- bromo-4 bromo chalcone (Ic) and 2'-hydroxy-4'- methyl-5'-bromo -4-dimethyl amino chalcone (Id) reacta with bromine in acetic acid gives chalcone dibromides (II a-d). The chalcone dibromide (II a-d). condenses with benzene 1,2- diamine (BDA) in presence of few drops of concentrated H2SO4 in methanol medium affords 2-(2'-hydroxy-4-methyl-5'-bromo) benzyl-3-(4"- substituted phenyl)- quinoxaline (III a-d). The structure of these compounds were confirmed by analytical and spectral data.

Keywords

Substituted quinozalines and Chalcone.

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