Background: Gastrointestinal (GI) tract tumors comprise a diverse group of neoplasms with varying clinical behavior and histopathological patterns. Their incidence is increasing worldwide, with notable regional differences in site distribution and tumor types. Early diagnosis and detailed histopathological evaluation are essential for appropriate management. Studying clinicopathological patterns in tertiary care settings helps in understanding disease trends and improving diagnostic and therapeutic approaches. Aims: To evaluate the clinical profile, anatomical distribution, and histopathological spectrum of gastrointestinal tract tumors in a tertiary care center. Materials and Methods: This prospective observational study was conducted over a period of 10 months at a tertiary care center, including 55 patients diagnosed with gastrointestinal tract tumors. Patients presenting with symptoms suggestive of gastrointestinal malignancy were evaluated clinically and investigated with laboratory tests, imaging, and endoscopy. Biopsy or resection specimens were subjected to histopathological examination. Tumors were classified based on site and histological type, and data were analyzed statistically. Results: Out of 55 patients, adenocarcinoma was the most common histological type, seen in 39 (70.91%) cases. Squamous cell carcinoma was observed in 7 (12.73%) cases, all involving the esophagus. Signet ring cell carcinoma was identified in 5 (9.09%) cases. Gastrointestinal stromal tumors (GIST) were seen in 2 (3.64%) cases, and lymphoma in 1 (1.82%) case. The stomach was the most frequently involved site, accounting for 25 (45.45%) cases, followed by the colorectal region in 21 (38.18%) cases. The esophagus was involved in 7 (12.73%) cases, while the small intestine was the least common site with 2 (3.64%) cases. Conclusion: Gastrointestinal tumors in this study predominantly consisted of adenocarcinoma, with the stomach being the most commonly affected site. Histopathological evaluation remains essential for accurate diagnosis and treatment planning. Early detection strategies and awareness are crucial for improving patient outcomes.

Gastrointestinal tumors, Adenocarcinoma, Stomach cancer, Colorectal cancer, Histopathology, Oesophageal cancer