Polycystic ovary syndrome is one of the most common endocrine and gynaecological conditions in reproductive-age women‚ associated with reproductive‚ metabolic and psychological consequences․ Though the prevalence of depression and anxiety in PCOS is widely reported‚ there are limited data from Indian clinics․ Therefore‚ this cross-sectional study intended to assess the prevalence of depression and anxiety and the association between depression and anxiety with socio-demographic‚ clinical‚ lifestyle-related and mental well-being-related factors in women with PCOS attending selected health care facilities in Varanasi‚ Uttar Pradesh‚ India․ The sample of 160 women with age ranges of 15 to 40 years‚ who were diagnosed with PCOS‚ obtained data using a questionnaire covering socio-demographic factors‚ clinical factors‚ lifestyle factors‚ the Hospital Anxiety and Depression Scale and the WHO-Five Well-Being Index․ Analyses included descriptive statistics‚ chi-square test‚ correlation coefficients and binary logistic regression analysis․ 44․4% had clinically meaningful depression‚ 55% had clinically meaningful anxiety symptoms and 28․1% had poor mental well-being․ Depression was considerably associated with abdominal obesity‚ hirsutism‚ snoring‚ sleep disturbance and poor mental well-being․ Anxiety was associated with poor mental well-being‚ hirsutism‚ alcohol drinking‚ having children‚ irregular menstruation‚ and sleep disturbance․ Multiple regression analysis found that poor mental well-being was the strongest predictor of depression and anxiety‚ indicating that women with PCOS require assessment beyond reproductive/ metabolic criteria․ Routine screening for depression‚ anxiety‚ sleep disturbance and poor mental well-being should be undertaken for PCOS in order to enable early counselling‚ lifestyle interventions and integrated clinical care․

Polycystic ovary syndrome, depression, anxiety, mental well-being, Varanasi, women’s health, HADS, WHO-5, psychological distress.