Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, often accompanied by reproductive, metabolic, and psychological complications. Mental health disorders such as anxiety and depression are increasingly recognized as significant comorbidities in PCOS, yet their burden and correlates in Indian populations remain underexplored. Aim: To determine the prevalence of anxiety and depression among women with PCOS and assess their association with demographic and clinical factors. Methods: This hospital-based cross-sectional study included 240 women aged 18–40 years diagnosed with PCOS according to Rotterdam criteria. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Demographic and clinical variables were recorded, and statistical analyses were performed using Chi-square tests and Welch’s t-tests, with significance set at p < 0.05. Results: Anxiety was present in 36.3% (95% CI: 30.2%–42.3%) and depression in 30.8% (95% CI: 25.0%–36.7%) of participants. Women with anxiety had significantly higher mean BMI compared to those without (28.5 ± 4.1 vs. 26.5 ± 4.1 kg/m²; p < 0.001), while those with depression were slightly older (28.8 ± 4.6 vs. 27.1 ± 4.6 years; p = 0.009). Higher BMI, irregular menstruation, hirsutism, younger age, and marital status were significantly associated with both anxiety and depression. Conclusion: Anxiety and depression are prevalent in women with PCOS and strongly linked to specific metabolic and reproductive features. Routine mental health screening and holistic management should be integrated into PCOS care pathways.

Polycystic Ovary Syndrome, Anxiety, Depression