Neuroscience and Its Application in Drug Delivery Systems: A Review of Blood-Brain Barrier Crossing Strategies

Volume 6 No 1 (2008)

Arnabaditya Mohanty, Lalatendu Mohanty

DOI: 10.14704/nq.2008.6.1.162

Abstract

The blood–brain barrier (BBB) is one of the major obstacles in neuropharmacology. It blocks the entry of about 98% of small-molecule drugs and nearly all large-molecule therapeutics into the brain. While this selective permeability is important for maintaining brain homeostasis and protecting neural tissue from harmful agents

Keywords

Blood–brain barrier, drug delivery, nanoparticles, liposomes, receptor-mediated targeting, neurodegenerative diseases, central nervous system

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