Background: Rabies, a fatal but preventable viral disease, remains a significant public health problem in India. Despite access to post-exposure prophylaxis (PEP), rabies-related deaths continue to occur, highlighting potential gaps in public knowledge and practice. Objectives: To assess the knowledge, attitudes, and practices (KAP) related to rabies among patients and bystanders attending a tertiary care hospital in Kerala and to identify key determinants influencing them. Methods: A cross-sectional study was conducted among 201 participants aged above 18 years at Government Medical College, Ernakulam, during August 2022. Data were collected using a pre-tested, semi-structured questionnaire in Malayalam, administered via interviews. The data were analyzed using SPSS; associations were tested using the chi-square test. Results: Most participants had average or above-average knowledge about rabies, yet misconceptions regarding fatality and PEP persisted. Educational status was significantly associated with better knowledge and preventive practices. Television and newspapers were the main sources of information. Gaps in awareness about animal welfare organizations and responsible pet ownership laws were identified. Vaccination following animal bites was not universal due to various factors, including cost and perceived risk.

Rabies, Knowledge Attitude Practice, Animal Bites, Post-Exposure Prophylaxis