Background: Cardiovascular disease is a leading cause of morbidity and mortality among patients with Diabetes Mellitus. Chronic inflammation plays a key role in atherosclerosis, and High-Sensitivity C-Reactive Protein has emerged as an important marker of cardiovascular risk in patients with Coronary Artery Disease. Aim: To evaluate the role of hs-CRP as a marker of cardiovascular risk in diabetic patients with coronary artery disease. Methods: This hospital-based cross-sectional study was conducted in the Department of Emergency Medicine at Sree Mookambika Institute of Medical Sciences from February 2025 to February 2026. Adult patients with diabetes and confirmed coronary artery disease were included. Clinical data were recorded, and blood samples were analyzed for hs-CRP levels, glycemic status, and lipid profile. Patients were categorized based on hs-CRP risk levels, and associations with clinical parameters were assessed using appropriate statistical methods. Results: The mean age of participants was 54.08±8.8 years, with a near-equal gender distribution. Elevated hs-CRP levels were observed in all patients, with 75% in the high-risk category. No significant correlation was found between hs-CRP and glycemic control (p=0.444). However, a significant association was noted between elevated hs-CRP levels and severity of coronary vessel involvement (p=0.002). hs-CRP levels also showed significant correlation with adverse lipid parameters (p<0.05). Conclusion: hs-CRP is a useful inflammatory biomarker for assessing cardiovascular risk and disease severity in diabetic patients with coronary artery disease. Its significant association with dyslipidemia and vessel involvement highlights its value in risk stratification and clinical management.

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