Objective: Objectives of the study were Evaluation of Epidemiological Patterns, Clinical manifestations and Outcomes of Sepsis in adult Patients at a tertiary care hospital. Background: The incidence of sepsis is increasing, especially in populations with advanced age and comorbidities. It is now estimated that sepsis is a leading cause of mortality and critical illness worldwide. The Epidemiological data regarding sepsis, septic shock and organ involvement is mainly from western literature. Data from India, especially central India, are less when compared to western data. In this background the authors conducted a study in a tertiary care hospital in central India. Methods: prospective observational study was conducted over six months, from the time period of July 2024 to December 2024.The study population was patients above 18 yrs admitted with sepsis and septic shock. The study was conducted in a tertiary care hospital in India. Various characteristics like comorbidities, organ involvement, septic shock, sofa score, need for ventilatory support, RRT support and outcome data was collected. Results: In this study, 70 patients who satisfied the Surviving Sepsis Campaign guidelines were included. Out of 70 patients enrolled, 38 patients(54.37%)were male , 32 (45.71%) were female. Hypertension was the most prevalent comorbidity, followed by diabetes and chronic kidney disease. A significant proportion of patients presented with multiple comorbidities, which correlated with higher mortality rates. Out of 70 Patients 14 (20%) were in septic shock while 56 patients (80%) were in sepsis . Out of 14 patients with septic shock 6 patients (42.83%) succumbed. 46 patients (82.14%) admitted with sepsis responded well and recovered. Overall mortality 20 (28.57%) out of 70 patients were noted. The predominant source of sepsis was respiratory tract infections and urinary tract infections followed by intra-abdominal and skin & soft tissue infections and the source remained unidentified in 6% (n 4) cases despite extensive workup. Gram-negative organisms predominated, representing 62% of positive cultures. Escherichia coli was the most frequently isolated pathogen (30.57%), followed by Klebsiella pneumoniae (21.53%). Among Gram-positive organisms, Staphylococcus aureus accounted for 18% of isolates, with methicillin-resistant strains comprising 54% of these cases. C-reactive protein and procalcitonin were elevated in most patients, indicating severe systemic inflammation. Conclusion: The results of this study show the significant impact of comorbidities on sepsis development and outcomes. Early identification of infection sources and appropriate antibiotic administration based on culture sensitivity improved patient outcomes, though mortality remained substantial in patients with multiple risk factors. Research is ongoing to identify actionable subtypes of sepsis and develop targeted therapy for host dysregulation.

Sepsis; Septic shock; Comorbidities; Inflammatory markers; Mortality.