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Volume 19 No 4 (2021)
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Diagnosis of Carpal Tunnel Syndrome: The Role of RANTES
Ihsan M. Ajeena , Rihab H. Al-Mudhafar , Iman J. Al-Awadi , Hasanain A. Al-Khalidi , Nawrass J. Alsalihi
Abstract
Carpal tunnel syndrome (CTS) is regarded as most frequent entrapment neuropathy in upper extremities with high
prevalence in females. It is a multi-factorial disease that had signs and symptoms due to compression of median nerve
at the carpal tunnel in wrist, although may be asymptomatic. Immune system has been recognized as the main factor
of neuropathic pain. Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) is among the cytokines
that revealed a dysregulated pattern of neuropathy specific cytokine profile in CTS and, in human, it is encoded by
CCL5 gene. Sixty-four patients suffering from CTS were enrolled in this controlled cross sectional study
Keywords
Carpal Tunnel Syndrome, CCL5, RANTES.
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