Background: Gestational diabetes mellitus (GDM) poses significant health risks to both mothers and their newborns. Understanding its prevalence among first-time mothers can guide better screening strategies and healthcare interventions. Objective: This study aimed to determine the prevalence of GDM among first-time mothers and identify associated demographic and clinical risk factors. Methods: A cross-sectional analysis was conducted involving 160 first-time pregnant women at a tertiary care hospital. Participants were screened for GDM using the Oral Glucose Tolerance Test (OGTT) between 24 and 28 weeks of gestation. Data on age, body mass index (BMI), and family history of diabetes were also collected and analyzed. Results: Out of 160 participants, 24 (15%) were diagnosed with GDM. Statistical analysis revealed significant associations between GDM and factors such as age ≥ 30 years (p=0.029), BMI ≥ 25 kg/m² (p=0.017), and a positive family history of diabetes (p=0.045). These findings underscore the importance of considering these factors in prenatal screening programs. Conclusion: The prevalence of GDM in this cohort of first-time mothers was 15%. The significant associations with age, BMI, and family history highlight the need for targeted screening based on these risk factors. These results support the implementation of routine GDM screening for all pregnant women, particularly those at higher risk

Gestational Diabetes, First-Time Mothers, Prenatal Screening.