Introduction: Patients with chronic liver illness may experience acute chronic liver failure (ACLF), a severe and complicated syndrome marked by. Because of its quick progression, high death rate, and unique pathophysiological mechanism, acute chronic liver failure (ACLF) is a unique. Methodology: After giving their informed written agreement, hospitalized patients who met the inclusion and exclusion criteria were enrolled. Each patient's acid-base status was assessed using an arterial blood gas (ABG) test. The Quick Sequential Organ Failure Assessment (qSOFA) score-calculating parameters were noted. Relevant investigations included serum bilirubin, SGOT/SGPT, total protein, serum albumin, blood urea, serum creatinine, electrolytes, serum ammonia, PT/INR, ABG, ascitic. Results: The most common acid-base abnormality among those found was respiratory alkalosis (63%), was followed by metabolic acidosis (30.4%). a strong correlation (p < 0.001) between metabolic acidosis and higher qSOFA scores, suggesting that patients with more severe acid-base. the correlation between clinical consequences and qSOFA scores. Complications including HRS and SBP were considerably more common in those with higher qSOFA scores. Serum creatinine >1.5 mg/dL, increased INR values suggesting coagulopathy, and substantially altered consciousness based on Glasgow Coma Scale scores were. The qSOFA score indicates that metabolic acidosis, in particular, is prevalent in ACLF and strongly correlated with the severity of the disease. Conclusion: Higher qSOFA scores were found to be statistically significantly associated with metabolic acidosis, indicating that deteriorating acid-base imbalance is associated with more severe illness and organ dysfunction.

Acute on chronic liver failure, qSOFA scores, acid-base abnormality