Background: Guillain-Barré Syndrome is an acute immune-mediated polyradiculoneuropathy and an important cause of acute flaccid paralysis worldwide. The clinical presentation and outcomes of Guillain-Barré Syndrome vary considerably, and early identification of predictors of poor outcome is important for improving patient management and reducing morbidity and mortality. Objectives: To evaluate the clinical profile, electrophysiological characteristics, and predictors of in-hospital outcome among patients with Guillain-Barré Syndrome admitted to a tertiary care hospital in Rajasthan. Methods: A prospective observational study was conducted in the Department of General Medicine and associated Neurology services of a tertiary care teaching hospital in Rajasthan from March 2025 to March 2026. A total of 45 patients diagnosed with Guillain-Barré Syndrome were enrolled using consecutive sampling. Demographic details, antecedent illnesses, clinical manifestations, neurological examination findings, cerebrospinal fluid analysis, electrophysiological patterns, treatment modalities, and clinical outcomes were recorded using a structured case record form. Statistical analysis was performed using IBM SPSS Statistics version 26.0. Categorical variables were analyzed using Chi-square test or Fisher’s exact test, and a p-value of <0.05 was considered statistically significant. Results: The majority of patients belonged to the 31–45 years age group, and males constituted 62.2% of the study population. Antecedent upper respiratory tract infection was the most common preceding illness. Ascending paralysis (86.7%) and areflexia (91.1%) were the predominant clinical features. Cranial nerve involvement was observed in 31.1% of patients, while autonomic dysfunction and respiratory muscle involvement were noted in 22.2% and 17.8% of cases, respectively. Acute inflammatory demyelinating polyneuropathy was the most common electrophysiological subtype (57.8%). Mechanical ventilation was required in 15.6% of patients, and mortality was observed in 4.4% of cases. Older age, cranial nerve involvement, autonomic dysfunction, respiratory involvement, axonal electrophysiological subtype, and ICU admission showed significant association with poor outcome. Conclusion: Guillain-Barré Syndrome remains an important neurological emergency associated with considerable morbidity. Early recognition of predictors such as respiratory involvement, autonomic dysfunction, and axonal variants may facilitate timely intensive management and improve clinical outcomes. Strengthening critical care and rehabilitation services may further reduce disease burden in tertiary care settings.

Guillain-Barré Syndrome; Acute flaccid paralysis; AIDP; Outcome predictors; Mechanical ventilation; Peripheral neuropathy; Rajasthan