Background: Septic shock is a life-threatening condition associated with high mortality. Early risk stratification using reliable scoring systems such as the quick Sequential Organ Failure Assessment (qSOFA) score and the Acute Physiology and Chronic Health Evaluation II (APACHE II) score is essential for improving clinical outcomes. Aim: To evaluate and compare the effectiveness of qSOFA and APACHE II scores in predicting outcomes in patients with septic shock. Methods: This longitudinal follow-up study was conducted at Sree Mookambika Institute of Medical Sciences from August 2025 to feburary 2026. A total of 312 patients aged 18–60 years with septic shock were included. qSOFA score was assessed at admission, and APACHE II score was calculated within 24 hours. Patients were followed until discharge or death. Statistical analysis was performed using appropriate methods, and p < 0.05 was considered significant. Results: The mean age of patients was 51 ± 6.6 years, with a nearly equal gender distribution. A majority (73.72%) had qSOFA score >2, and 33.01% had APACHE II score >17. Overall mortality was 41.35%. A significant association was observed between higher qSOFA scores and mortality (p < 0.001). Higher APACHE II scores were also associated with poor outcomes. Conclusion: Both qSOFA and APACHE II scores are effective in predicting outcomes in septic shock. qSOFA serves as a rapid bedside tool, while APACHE II provides detailed prognostic assessment. Their combined use may enhance early risk stratification and improve patient outcomes.

Septic shock, qSOFA, APACHE II, mortality, prognosis, ICU.