Background: Asthma is a chronic inflammatory airway disease increasingly recognized for its systemic effects, including a potential association with cardiovascular disease (CVD). Chronic inflammation may contribute to increased cardiovascular risk in asthmatic patients. Aim: To evaluate asthma as a predictor of cardiovascular disease events and to assess the role of inflammatory markers in this association. Methods: This observational analytical study was conducted at Sree Mookambika Institute of Medical Sciences from January 2025 to January 2026. A total of 300 asthma patients were enrolled and divided into two groups: asthma with CVD (n = 150) and asthma without CVD (n = 150). Clinical, biochemical, and functional parameters including CRP, IL-6, FEV1, and LVEF were assessed. Statistical analysis included Chi-square test, independent t-test, and logistic regression. Results: Elevated CRP levels (>3 mg/L) were significantly higher in the CVD group (63.3%) compared to the non-CVD group (32.0%) (p < 0.001). FEV1 and LVEF were significantly lower in the CVD group. During follow-up, 25% of patients experienced cardiovascular events compared to 10% in controls (p = 0.001). CRP (OR = 2.1, p = 0.002) and IL-6 levels were identified as independent predictors. Kaplan–Meier analysis showed reduced event-free survival in patients with high CRP levels. Conclusion: Asthma is associated with increased cardiovascular risk, with systemic inflammation playing a central role. Monitoring inflammatory markers may aid in early identification and risk stratification of high-risk patients.

Asthma, cardiovascular disease, CRP, IL-6, inflammation, risk prediction.