We considered a system of microtubule(s) (MTs) immersed in a water reservoir in order to investigate its thermodynamic properties and computation (processing) potential. We started with the “double frustration” concept for a single microtubule and next extended our considerations to an MT multi-cluster. We probed the influence of the physical anomalies of water in compressibility and the speed of sound, where acoustic phonons that are conjugated to the stress fluctuations that are produced by changes in symmetry, are possible carriers of information and the cause of ‘calculation’ enhancement at the physiological temperatures of human brain. We showed that the timing of the internal clock can be as high as 117 GHz and that the long-range coherence should be maintained for about 0.1 ms, which is a reasonable dynamical timescale. We advocated that some ‘local’, ‘intermediate’ and ‘extended states’ of our mind could be in relation to water temperature anomalies. We also suggested that the frustration scheme might introduce a direct link to the evolutionary survival paradigm in the case of the slow or fast computations that are performed by elementary systems able to perform basic calculations that can be identified with ‘thinking’

Acoustic phonons, decoherence, geometrical frustration, quantum biology, speed of sound