Background: Hypertension is a major risk factor for cardiovascular disease, in which arterial stiffness plays a central role. Pulse pressure (PP), an indirect indicator of large artery stiffness, has emerged as an independent predictor of adverse cardiovascular outcomes. This study aimed to evaluate the relationship between PP and lipid profile parameters among normotensive individuals and hypertensive patients with differing PP levels. Methods: This cross-sectional study included 112 adults aged 35–60 years (58% males, 42% females). Participants were categorized into three groups: normotensives (Group A, n=36), hypertensives with normal PP (Group B, n=43), and hypertensives with wide PP (Group C, n=33). Serum lipid parameters—total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and the total cholesterol/HDL ratio—were analyzed and compared across groups using unpaired t-tests in SPSS version 25. Results: Lipid parameters were progressively higher from normotensives to hypertensives with wide PP. Hypertensive participants exhibited significantly elevated total cholesterol, LDL-C, triglycerides, and TC/HDL ratio compared to normotensives (p<0.05). HDL-C levels were significantly lower in hypertensives; however, no significant difference was observed between hypertensive subgroups based on PP width. Conclusion: Wide pulse pressure is associated with an adverse lipid profile in hypertensive individuals, highlighting PP as a simple and clinically relevant marker for cardiovascular risk assessment.

Pulse pressure; Hypertension; Lipid profile; Arterial stiffness; Cardiovascular risk.