Antibiotic resistance is a worldwide problem that can cross international boundaries and spread between continents very easily and speedily. World health readers have described antibiotic resistant organisms as “nightmare bacteria” that pose a “catastrophic threat” to people in every country in the world. The use of antibiotic is the single most important factor leading to antibiotic resistance around the world. Emergence of resistance to multiple antimicrobial agents in pathogenic bacteria has become a significant public health threat as there are fewer, or even sometimes no, effective antimicrobial agents available for infections caused by these bacteria. Gram-positive and Gram-negative bacteria are both affected by the emergence and rise of antimicrobial resistance. As this problem continues to grow, harmonized definitions with which to describe and classify bacteria that are resistant to multiple antimicrobial agents are needed, so that epidemiological surveillance data can be reliably collected and compared across healthcare settings and countries. Present study will help to know the prevalent drug-resistant bacterial strain and their resistance pattern and also to detect the incidence of Multi drug resistant (MDR), Extensive drug resistant (XDR) in Gram positive bacterial isolates in tertiary care hospital. This Prospective study will be conducted in central laboratory, Department of Microbiology, F.H medical college & hospital, Tundla Agra. Total 129 gram positive bacterial isolates were obtained in two and half year study. Male patients 53% and female patient's 47%. Most of the bacteria isolated from Pus specimen 31 followed by urine sample 19. MDR was reported 65% and XDR 34.3%, Staphylococcus aureus 62 isolates was the most reported bacteria in our study followed by CoNS 35.

Multi Drug resistant, Extensive Drug Resistance, Gram positive cocci.