Background: Liver cirrhosis is a progressive disease associated with significant morbidity and mortality. Assessment of disease severity is essential for prognosis and management. Serum prolactin, influenced by altered neurotransmitter activity in cirrhosis, has been proposed as a potential biomarker. Aim: To evaluate the diagnostic and prognostic significance of serum prolactin levels in cirrhosis and correlate them with the Child–Pugh score. Materials and Methods: This prospective study was conducted in the Department of Emergency Medicine at Sree Mookambika Institute of Medical Sciences from July 2025 to March 2026. A total of 120 patients with clinically, biochemically, and ultrasonographically confirmed cirrhosis were included. Serum prolactin levels were measured and correlated with Child–Pugh classification. Statistical analysis was performed using SPSS version 25.0. Results: The majority of patients belonged to Child–Pugh Class C, followed by Class B and Class A. Serum prolactin levels were significantly elevated in patients with advanced cirrhosis and showed a positive correlation with Child–Pugh score. Higher prolactin levels were also associated with complications such as ascites, esophageal varices, and hepatic encephalopathy. Conclusion: Serum prolactin levels correlate well with disease severity in cirrhosis and may serve as a simple, cost-effective prognostic biomarker for assessing progression and complications of liver disease.

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