Background: Prolonged computer use has emerged as a significant risk factor for dry eye disease (DED), affecting millions of working professionals globally. This study aimed to assess the prevalence and severity of dry eye symptoms among computer users and identify associated risk factors. Methods: A cross-sectional study was conducted at a tertiary care ophthalmology center. A total of 384 participants aged 18-60 years with computer use ≥4 hours daily were enrolled. Dry eye assessment included the Ocular Surface Disease Index (OSDI) questionnaire, tear break-up time (TBUT), Schirmer's test, and corneal fluorescein staining. Demographic data, work-related factors, and environmental conditions were recorded. Statistical analysis employed chi-square tests, independent t-tests, and multivariate logistic regression. Results: The prevalence of dry eye disease was 68.2% (262/384 participants). The mean OSDI score was 42.8 ± 18.6 in DED patients versus 16.4 ± 8.2 in controls (p<0.001). Mean TBUT was significantly reduced in DED patients (5.8 ± 2.4 seconds) compared to controls (12.4 ± 3.1 seconds, p<0.001). Significant risk factors included daily computer use >8 hours (OR=3.42, 95% CI: 1.98-5.91, p<0.001), contact lens wear (OR=2.76, 95% CI: 1.52-5.01, p=0.001), and air-conditioned environment (OR=2.18, 95% CI: 1.31-3.62, p=0.003). Female gender, inadequate blinking, and lack of screen breaks also significantly correlated with DED. Conclusion: Dry eye disease is highly prevalent among computer users, with prolonged screen time being the most significant modifiable risk factor. Implementation of preventive strategies and regular eye care are essential for this vulnerable population.

dry eye disease, computer vision syndrome, ocular surface disease index, tear break-up time, occupational health, digital eye strain