DOI: 10.14704/nq.2018.16.5.1356

Clinical Features, Diagnosis and Treatment of Children's Wernicke’s Encephalopathy

Yinsen Song, Yinghui Zhang, PengBo Guo, Lili Ge, Bo Zhang, Lei Liu, Jingui Kong, Chongfen Chen, Shuying Luo


To explore the clinical features, diagnosis, and treatment of Wernicke’s encephalopathy (WE) in children and raise awareness of the disease. Summarize the clinical manifestations, diagnosis, and treatment characteristics of a WE case in a child patient with severe sepsis as the first manifestation and review the literatures of children cases reported at home and abroad in recent years. Children's WE often have no specific clinical manifestations, so the misdiagnosis rate is high. The MRI features of the brain show signs of symmetric abnormalities in bilateral mammillary body, basal ganglia, and cerebral periaqueductal area, etc. The characteristic brain MRI abnormal signal combined with rapid response after clinical thiamine treatment is helpful for clinical diagnosis. Early and timely supplementation of large doses of thiamine resulted in rapid improvement of neurological abnormalities in most cases with good prognosis.


Wernicke’s Encephalopathy (WE), Children, Severe Sepsis

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Basit S, Elsas T, Kvistad KA, Høsøien LS. Wernicke’s encephalopathy because of pancreattitig in a young boy. Acta Ophthalmologica 2011; 89(8): e656-57.

Bentham P, Callaghan R. Thiamine for Wernicke’s Korsakoff syndrome in people at risk from alcohol abuse. Cochrane Database of Systematic Reviews 2004; 1(1): CD004033.

Cooke CA, Hicks E, Page AB, Mc Kinstry S. An atypical presentation of Wernicke’s encephalopathy in an ll-year-old child. Eye 2006; 20(12): 1418-20.

da Cruz LH, Domingues RC, Vilanova I, Gasparetto EL. MR imaging findings in Wernicke encephalopathy: nonalcoholics may be similar to alcoholics. American Journal of Neuroradiology 2010;31(6):E54-55.

Guerrini I, Thomson AD, Gurling HM. Molecular genetics of alcohol-related brain damage. Alcohol & Alcoholism 2008; 44(2):166-70.

Hazell AS, Butterworth RF. Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation. Alcohol & Alcoholism 2009; 44(2):141-47.

Liu YT, Fuh JL, Lirng JF, Li AF, Ho DM, Wang SJ. Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy. Clinical Neurology and Neurosurgery 2006; 108(7):682-87.

Nishida M, Sato H, Kobayashi N, Morimoto M, Hamaoka K. Wernicke’s encephalopathy in a patient with nephrotic syndrome. European Journal of Pediatrics 2009; 168(6):731-34.

Peters TE, Parvin M, Petersen C, Faircloth VC, Levine RL. A case report of Wernicke’s encephalopathy in a pediatric patient with anorexia nervosa-restricting type. Journal of Adolescent Health 2007; 40(4):376-83.

Sechi G, Serra A. Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. The Lancet Neurology 2007; 6(5):442-55.

Zuccoli G, Pipitone N. Neuroimaging findings in acute Wernicke's encephalopathy: review of the literature. American Journal of Roentgenology 2009; 192(2):501-08.

Zuccoli G, Siddiqui N, Bailey A, Bartoletti SC. Neuroimaging findings in pediatric Wernicke encephalopathy: a review. Neuroradiology 2010; 52(6):523-29.

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