ojs2 has produced an error Message: USER NOTICE: Deprecated import of a partially qualified class name. In file: /home/neuroqua/public_html/lib/pkp/includes/functions.inc.php At line: 34 Stacktrace: File: (unknown) line (unknown) Function: PKPApplication->errorHandler(1024, "Deprecated import of a partially qualified class name.", "/home/neuroqua/public_html/lib/pkp/includes/functions.inc.php", 34, Array(3)) File: /home/neuroqua/public_html/lib/pkp/includes/functions.inc.php line 34 Function: trigger_error("Deprecated import of a partially qualified class name.") File: /home/neuroqua/public_html/plugins/generic/reviewerIndex/ReviewerIndexPlugin.inc.php line 14 Function: import("classes.plugins.GenericPlugin") File: /home/neuroqua/public_html/plugins/generic/reviewerIndex/index.php line 18 Function: require_once("/home/neuroqua/public_html/plugins/generic/reviewerIndex/ReviewerIndexPlugin.inc.php") File: /home/neuroqua/public_html/lib/pkp/classes/plugins/PluginRegistry.inc.php line 221 Function: include("/home/neuroqua/public_html/plugins/generic/reviewerIndex/index.php") File: /home/neuroqua/public_html/lib/pkp/classes/plugins/PluginRegistry.inc.php line 107 Function: PluginRegistry->_instantiatePlugin("generic", "plugins/generic", "reviewerIndex", "ReviewerIndexPlugin") File: /home/neuroqua/public_html/lib/pkp/classes/core/Dispatcher.inc.php line 131 Function: PluginRegistry->loadCategory("generic", True) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php line 189 Function: Dispatcher->dispatch(Object(Request)) File: /home/neuroqua/public_html/index.php line 63 Function: PKPApplication->execute() Server info: OS: Linux PHP Version: 5.6.40 Apache Version: N/A DB Driver: mysqli DB server version: 10.2.27-MariaDB-cll-lve
ojs2 has produced an error Message: USER NOTICE: Deprecated function. In file: /home/neuroqua/public_html/classes/journal/Journal.inc.php At line: 259 Stacktrace: File: (unknown) line (unknown) Function: PKPApplication->errorHandler(1024, "Deprecated function.", "/home/neuroqua/public_html/classes/journal/Journal.inc.php", 259, Array(0)) File: /home/neuroqua/public_html/classes/journal/Journal.inc.php line 259 Function: trigger_error("Deprecated function.") File: /home/neuroqua/public_html/plugins/generic/reviewerIndex/ReviewerIndexPlugin.inc.php line 96 Function: Journal->getJournalId() File: /home/neuroqua/public_html/plugins/generic/reviewerIndex/ReviewerIndexPlugin.inc.php line 49 Function: ReviewerIndexPlugin->getEnabled() File: /home/neuroqua/public_html/lib/pkp/classes/plugins/PluginRegistry.inc.php line 65 Function: ReviewerIndexPlugin->register("generic", "plugins/generic/reviewerIndex") File: /home/neuroqua/public_html/lib/pkp/classes/plugins/PluginRegistry.inc.php line 136 Function: PluginRegistry->register("generic", Object(ReviewerIndexPlugin), "plugins/generic/reviewerIndex") File: /home/neuroqua/public_html/lib/pkp/classes/core/Dispatcher.inc.php line 131 Function: PluginRegistry->loadCategory("generic", True) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php line 189 Function: Dispatcher->dispatch(Object(Request)) File: /home/neuroqua/public_html/index.php line 63 Function: PKPApplication->execute() Server info: OS: Linux PHP Version: 5.6.40 Apache Version: N/A DB Driver: mysqli DB server version: 10.2.27-MariaDB-cll-lve
ojs2 has produced an error Message: USER NOTICE: Deprecated function. In file: /home/neuroqua/public_html/classes/article/Article.inc.php At line: 70 Stacktrace: File: (unknown) line (unknown) Function: PKPApplication->errorHandler(1024, "Deprecated function.", "/home/neuroqua/public_html/classes/article/Article.inc.php", 70, Array(0)) File: /home/neuroqua/public_html/classes/article/Article.inc.php line 70 Function: trigger_error("Deprecated function.") File: /home/neuroqua/public_html/pages/article/ArticleHandler.inc.php line 208 Function: Article->getArticleTitle() File: (unknown) line (unknown) Function: ArticleHandler->view(Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPRouter.inc.php line 370 Function: call_user_func(Array(2), Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPPageRouter.inc.php line 266 Function: PKPRouter->_authorizeInitializeAndCallRequest(Array(2), Object(Request), Array(1), False) File: /home/neuroqua/public_html/lib/pkp/classes/core/Dispatcher.inc.php line 133 Function: PKPPageRouter->route(Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php line 189 Function: Dispatcher->dispatch(Object(Request)) File: /home/neuroqua/public_html/index.php line 63 Function: PKPApplication->execute() Server info: OS: Linux PHP Version: 5.6.40 Apache Version: N/A DB Driver: mysqli DB server version: 10.2.27-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Cannot modify header information - headers already sent by (output started at /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php:392) In file: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php At line: 339 Stacktrace: File: (unknown) line (unknown) Function: PKPApplication->errorHandler(2, "Cannot modify header information - headers already sent by (output started at /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php:392)", "/home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php", 339, Array(7)) File: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php line 339 Function: header("Content-Type: text/html; charset=utf-8") File: /home/neuroqua/public_html/pages/article/ArticleHandler.inc.php line 235 Function: PKPTemplateManager->display("article/article.tpl") File: (unknown) line (unknown) Function: ArticleHandler->view(Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPRouter.inc.php line 370 Function: call_user_func(Array(2), Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPPageRouter.inc.php line 266 Function: PKPRouter->_authorizeInitializeAndCallRequest(Array(2), Object(Request), Array(1), False) File: /home/neuroqua/public_html/lib/pkp/classes/core/Dispatcher.inc.php line 133 Function: PKPPageRouter->route(Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php line 189 Function: Dispatcher->dispatch(Object(Request)) File: /home/neuroqua/public_html/index.php line 63 Function: PKPApplication->execute() Server info: OS: Linux PHP Version: 5.6.40 Apache Version: N/A DB Driver: mysqli DB server version: 10.2.27-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Cannot modify header information - headers already sent by (output started at /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php:392) In file: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php At line: 342 Stacktrace: File: (unknown) line (unknown) Function: PKPApplication->errorHandler(2, "Cannot modify header information - headers already sent by (output started at /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php:392)", "/home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php", 342, Array(7)) File: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php line 342 Function: header("Cache-Control: no-store") File: /home/neuroqua/public_html/pages/article/ArticleHandler.inc.php line 235 Function: PKPTemplateManager->display("article/article.tpl") File: (unknown) line (unknown) Function: ArticleHandler->view(Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPRouter.inc.php line 370 Function: call_user_func(Array(2), Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPPageRouter.inc.php line 266 Function: PKPRouter->_authorizeInitializeAndCallRequest(Array(2), Object(Request), Array(1), False) File: /home/neuroqua/public_html/lib/pkp/classes/core/Dispatcher.inc.php line 133 Function: PKPPageRouter->route(Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php line 189 Function: Dispatcher->dispatch(Object(Request)) File: /home/neuroqua/public_html/index.php line 63 Function: PKPApplication->execute() Server info: OS: Linux PHP Version: 5.6.40 Apache Version: N/A DB Driver: mysqli DB server version: 10.2.27-MariaDB-cll-lve
Conformational Dynamics and Thermal Cones of C Terminal Tubulin Tails in Neuronal Microtubules | Georgiev | NeuroQuantology


DOI: 10.14704/nq.2007.5.1.119

Conformational Dynamics and Thermal Cones of C Terminal Tubulin Tails in Neuronal Microtubules

Danko Georgiev, James F. Glazebrook

Abstract


In this paper we present a model for estimation of the C-terminal tubulin tail (CTT) dynamics in cytoskeletal microtubules of nerve cells. We show that the screened Coulomb interaction between a target CTT and the negatively charged microtubule surface as well as its immediate CTT neighbours results in confinement of the CTT motion within a restricted volume referred to as a thermal cone. Within the thermal cone the CTT motion is driven by the thermal fluctuations, while outside the thermal cone the CTT interaction energy with its environment is above the thermal energy solely due to repulsion from the negatively charged microtubule surface. Computations were performed for different CTT geometries and we have found that the CTT conformation with lowest energy is perpendicular to the microtubule surface. Since the coupling between a target CTT with its neighbour CTTs is 8 orders of magnitude below the thermal energy and considering the extremely short cytosolic Debye length of 0.79 nm, our results rule out generation and propagation of CTT conformational waves along the protofilament as a result of local CTT perturbations. The results as presented support a model in which the cytosolic electric fields and ionic currents generated by the neuronal excitations are “projected†onto the CTTs of underlying microtubules thus affecting their regulatory function of kinesin motion and MAP attachment/detachment.

Keywords


cytoskeleton; microtubule; C-terminal tubulin tail; screened potential; thermal cone; local perturbation; neuronal excitation

Full Text:

PDF

Supporting Agencies



ojs2 has produced an error Message: USER NOTICE: Deprecated function. In file: /home/neuroqua/public_html/classes/journal/Journal.inc.php At line: 259 Stacktrace: File: (unknown) line (unknown) Function: PKPApplication->errorHandler(1024, "Deprecated function.", "/home/neuroqua/public_html/classes/journal/Journal.inc.php", 259, Array(0)) File: /home/neuroqua/public_html/classes/journal/Journal.inc.php line 259 Function: trigger_error("Deprecated function.") File: /home/neuroqua/public_html/plugins/generic/piwik/PiwikPlugin.inc.php line 167 Function: Journal->getJournalId() File: (unknown) line (unknown) Function: PiwikPlugin->insertFooter("Templates::Article::Footer::PageFooter", Array(3)) File: /home/neuroqua/public_html/lib/pkp/classes/plugins/HookRegistry.inc.php line 83 Function: call_user_func(Array(2), "Templates::Article::Footer::PageFooter", Array(3)) File: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php line 703 Function: HookRegistry->call("Templates::Article::Footer::PageFooter", Array(3)) File: /home/neuroqua/public_html/cache/t_compile/%%CC^CCB^CCBBF62B%%footer.tpl.php line 55 Function: PKPTemplateManager->smartyCallHook(Array(1), Object(TemplateManager)) File: /home/neuroqua/public_html/lib/pkp/lib/smarty/Smarty.class.php line 1869 Function: include("/home/neuroqua/public_html/cache/t_compile/%%CC^CCB^CCBBF62B%%footer.tpl.php") File: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php line 210 Function: Smarty->_smarty_include(Array(2)) File: /home/neuroqua/public_html/cache/t_compile/%%38^38D^38D7420B%%article.tpl.php line 182 Function: PKPTemplateManager->_smarty_include(Array(2)) File: /home/neuroqua/public_html/lib/pkp/lib/smarty/Smarty.class.php line 1263 Function: include("/home/neuroqua/public_html/cache/t_compile/%%38^38D^38D7420B%%article.tpl.php") File: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php line 295 Function: Smarty->fetch("article/article.tpl", Null, Null, True) File: /home/neuroqua/public_html/lib/pkp/classes/template/PKPTemplateManager.inc.php line 346 Function: PKPTemplateManager->fetch("article/article.tpl", Null, Null, True) File: /home/neuroqua/public_html/pages/article/ArticleHandler.inc.php line 235 Function: PKPTemplateManager->display("article/article.tpl") File: (unknown) line (unknown) Function: ArticleHandler->view(Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPRouter.inc.php line 370 Function: call_user_func(Array(2), Array(1), Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPPageRouter.inc.php line 266 Function: PKPRouter->_authorizeInitializeAndCallRequest(Array(2), Object(Request), Array(1), False) File: /home/neuroqua/public_html/lib/pkp/classes/core/Dispatcher.inc.php line 133 Function: PKPPageRouter->route(Object(Request)) File: /home/neuroqua/public_html/lib/pkp/classes/core/PKPApplication.inc.php line 189 Function: Dispatcher->dispatch(Object(Request)) File: /home/neuroqua/public_html/index.php line 63 Function: PKPApplication->execute() Server info: OS: Linux PHP Version: 5.6.40 Apache Version: N/A DB Driver: mysqli DB server version: 10.2.27-MariaDB-cll-lve


| NeuroScience + QuantumPhysics> NeuroQuantology :: Copyright 2001-2019