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Home > Archives > Volume 20, No 12 (2022) > Article

DOI: 10.14704/nq.2022.20.12.NQ77009

COLON TARGETED DRUG DELIVERY SYSTEM: A SYSTEMIC REVIEW

KHUSHBOO JASRA1*, AMANDEEP SINGH2, NEELAM PAINULY3, KANCHAN SINGH4

Abstract

Day by day there are new developments in field of colon specific drug delivery system .colon is a site where both local and systemic delivery of drugs can take place. The colon is also receiving significant attention as a portal for the entry of drugs into the systemic circulation. Due to the lack of digestive enzymes, colon is considered as suitable site for the absorption of various drugs. Colon in recent days offers great advantages for drug its physiological condition enriched for prolonging drug release time for successful colon targeted drug delivery, the drug needs to be protected from absorption and/or the environment of the upper gastrointestinal tract and then be abruptly released into the colon. Local delivery allows topical treatment associated with the colon like Crohn’s disease, ulcerative colitis etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. However, treatment can be made effective if the drugs can be targeted directly into the colon thereby reducing the systemic side effects. A variety of delivery strategies and systems have been proposed for colonic targeting. Hence continuous efforts have been made on designing colon targeted drug delivery systems with improved site specificity and versatile drug release kinetics to fulfill different therapeutic needs. This article gives an overview on anatomy of the colon and approaches utilized for colon specific drug delivery.

Keywords

Colon, Colon specific drug delivery, Inflammatory Bowel Disease

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