DOI: 10.14704/nq.2022.20.11.NQ66344

Synthesis and Antimicrobial activity of N-7- Methyl Adenine and its metal complexes

Srimanta Kumar Das, Biswaranjan Behera, Chandra Shekhar Purohit

Abstract

Copper (II) and silver (I) metal complexesof N-9-alkyladenine are well known in the literature. These studies reveal various important properties of nucleobases in the biological environment. However, N-alkyl-methyl adenine, an unnatural derivative of adenine, is very less studied. The aim of this study is to prepare copper and silver analogs of N-7- methyl adenine and study their properties. The Copper (II) metal salts were reacted with ligand with molar ratio M: L (1:1), (0.5:1) and silver metal salt with ligand molar ratio (1:1). The synthesized compound and prepared metal complexes were characterized and antibacterial activity against gram-negative, grampositiveandonefungal species carried out.The resultsof these studies are reported here.

Keywords

N-7-methyl Adenine, 6-chloro purine,N-7-Methyl adenine:Cu complex,N-7-Methyl adenine:Ag complex,antibacterial,antifungal activity.

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