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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66324

Preliminary phytochemical screening and effect on insomnia in epileptic rats by using a herbal drug fennel plant.

Shashi Singh, Pallavi tiwari, Dr. Manoj Kumar Mishra, Mayank Srivastava, Saurav Ghosal, Mohd Asad Farooqi, Sushma Yadav

Abstract

Because of increased stress and changing living conditions, central nervous system disorders are a major concern in today's world. Because epilepsy is one of the most common CNS disorders, and because current antiepileptic drug treatments have a number of side effects, the current study was designed to evaluate the effect of Foeniculum vulgare on GTC seizures, as well as its effect on memory retention in seizure-induced rats, and the role of monoamines in seizure protection and memory impairment. To investigate the effect on GTC, an electro convulsiometer was used to administer a maximum electro shock (150mA intensity for 0.2 sec) after 14 days of treatment with Foeniculum vulgare (300 and 500 mg/kg). Before beginning treatment, rats were trained for conditioned avoidance responses, and the effect on memory was studied using an Actophotometer and rotarod. The percent reduction in time demonstrated that Foeniculum vulgare had potential antiepileptic and memory retentive effects.

Keywords

Epilepsy, Foeniculum vulgare, Actophotometer, Roda rod.

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