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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66256

Serum Heart-Type Fatty Acid Binding Protein as A Diagnostic and Prognostic Predictor of Adverse Outcome in Children with Congestive Heart Failure

Eman Mahmoud Elmoughazy, Laila Rasslan Abd Al Aziz, Naglaa Ali Khalifa, Mohammed Saeed Ahmed

Abstract

Background:Pediatric heart failure (HF) is a clinical and pathophysiological illness brought on by ventricular dysfunction, volume or pressure overload, either singularly or in combination. Aim of study: To estimate serum level of H-FABP before and after treatment of congestive heart failure, and correlate its level with severity of the disease. Patients and methods: This is a cohort case control research that was carried out in the cardiology unit of the pediatric department of Zagazig university hospitals between January 2018 and December 2018. (January 2019). This study included 54 children, who were divided into two groups: group (1), which comprised (27) children with CHF, and group (2), which included (27) children with no major history of any cardiovascular or systemic disorders. Results: In cases, HFABP levels were significantly higher than in the control group. There was also a significant difference in blood H-FABP levels in our patients before and after treatment (5.6 5.6 ng/ml vs. 2.1 0.61 ng/ml). Conclusion: In children with heart failure, H-FABP may be used as a diagnostic and prognostic indicator of poor outcome.

Keywords

Heart failure (HF), Heart-type fatty acid-binding protein (H-FABP), Serum level

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