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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66220

A STUDY ON FORMULATION, EVALUATION AND CHARACTERIZATION OF FLOATING DRUG DELIVERY SYSTEM (KETOCONAZOLE)

Jaswant Singh,Harshita Gupta,Deepak Katiyar,Dr.Prashant Kumar

Abstract

This study's goal was to develop a gastro-retentive Ketoconazole direct compression technology medication delivery system. Ketoconazole has 56 % bioavailability subsequently, immediately wiped out from blood course and required regular dosing. The ketoconazole stacked microspheres (F1-F9) of EC: HPMC were arranged utilizing different interaction factors like polymer proportion, drug focus, emulsifier fixation and blending speed.During in vitro buoyancy testing, the tablet axially and dramatically expanded. The tablet was seen to stay buoyant for 20–24 hours. The final formulation had a floating lag time of no more than 35 sec, and the tablet remained floatable throughout all experiments, releasing about 89.21% of the medication in 24 hours in vitro. When compared to formulations having HPMCK 4 M, it was discovered that the tablets containing HPMCK 15 M floated for a longer period of time.Ketoconazole was discovered to release in a way that resembled a synthesis of the zero order release, Hixson-Crowell, and Korsmeyer-Peppas models. The non-Fickian transport of the medication from tablets was confirmed, and the drug release from the tablets was sustained as intended.

Keywords

Ketoconazole, GRDDS, In Vitro Buoyancy, Floating Tablets.

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