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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66186

Alzheimer’s disease: Anatomy, Pathogenesis, Early diagnosis and Treatment. Review

Eman Rababah


Alzheimer’s disease (AD) is the most common neurodegenerative disease of the brain that causes dementia in elderly people. In fact, the pathological changes of the disease begin several years in different stages before the clear clinical symptoms of AD's dementia appear. The accumulation of t beta-amyloid plaques outside neurons and tau tangles protein inside neurons mainly in the entorhinal cortex and hippocampus area are the hallmark changes in the brain of patients with AD. A combination of medical, physical and neuropsychological tests is usually used to diagnose and determine the stage of the disease. Until now there is no effective treatment to stop the progression or cure AD and the current approaches aim at decreasing or to stabilizing the progression of the disease. This review discusses the brain anatomy changes associated with the disease, pathogenic hypothesis of the disease, early diagnosis, management and recommended approaches to inhibit the progression the disease.


Dementia, Amyloid Plaques, Neurofibrillary Tangles, hippocampus.ntroduction

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