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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66152

DESIGN AND EVALUATION OF SECNIDAZOLEORODISPERSIBLE TABLETS BY DIRECT COMPRESSION METHOD USING DIFFERENT SUPERDISINTEGRANTS

LOKSHANA.D, MOHAMED YASIK M, GAYATHRI.H,DAMODHARAN.N

Abstract

Oral Dispersible Tablets (ODTs) are patient friendly dosage form that rapidly disintegrate or dispersed in mouth without the need of water. In the present investigation twelve ODT formulations of Secnidazole, an antiemetic drug, were prepared using different superdisintegrants viz. Crospovidone, Croscarmellose sodium and sodium starch glycollate by direct compression method. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and in vitro disintegration time. Formulation F1,F4,F7,F10 contains croscarmellose sodium, F2,F5,F8,F11 contains crosspovidone and F3,F6,F9,F12 contains sodium starch glycolate. Among the formulations tablets of batch F5 containing crosspovidone (at 3.75%) showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compared to other formulations. It was concluded that superdisintegrants addition technique is a useful method for preparing oral dispersible tablets by direct compression method. Hence F5 was found to be optimized formulation and can be used for the preparation of orodispersible tablet of Secnidazole.

Keywords

Oral Dispersible tablet, Direct Compression,Secnidazole,Preformulation, Evaluation

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