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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66137

Formulation & In-Vitro Evaluation of Aminophylline Anhydrous Bioadhesive Tablets

Manish Gangwar, Dr. Sachin Kumar, Atul Sharma

Abstract

The formulation of the oral bioadhesive Aminophylline Anhydrous tablet, various hydrophilic polymers and their combinations were used in varying concentrations of mucoadhesive polymer like HPMC K4M, Carbopol 934, Ethyl Cellulose, Aspartame, Talc and Magnesium Stearate added to the formulation are essentially required to achieve in-vitro buoyancy, desirable drug release, and excellent bioadhesive strength. Tablets were subject to various evaluation parameters such as Hardness, Friability, Drug content, Weight Variation and in vitro drug release study. It was revealed that tablets of all batches had acceptable physical parameters. Tablets of batch F8 have good mucoadhesion along with in vitro drug release. It was observed that tablets of all batches followed the equation of Zero, 1st Order Release Kinetics, Korsmeyer and Peppas drug release profiles. Tablets of Batch F8 were selected as an optimum batch. Stability studies revealed that there was no significant change in the hardness, friability, drug content, and dissolution profile of formulation F8. Thus, this formulation was stable at different conditions of temperature. The present study shows that can be used for designing a mucoadhesive CR drug delivery system. Various hydrophilic polymers and their combinations were used in varying concentrations of mucoadhesive polymer like HPMC K4M, Carbopol 934; hence it may increase the therapeutic efficacy of the drug by increasing the bioavailability and patient compliance and stimulates the skeletal muscles

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