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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66132

Protective Effect of Methanolic Extract of Nardostachys Jatamansi Rhizomes on Aspirin plus Pylorus Ligation-Induced Gastric ulcer in Experimental Animals

Devarakonda Krishna Prasad, Bairam Ravindar, Vasam Mallikarjun, Cherukupally Srinivas, Shanmugarathinam Alagarsamy, Vasudha Bakshi, Kola Venu


Ulcer is the condition of stomach mucosa continuity. Peptic ulcer is caused because of imbalance between defensive factors and aggressive factors. The herbaceous crop of Nardostachys jatamansi DC (Valerianaceae family) is the herbal agent whose therapeutic herbal agent is its rhizome. The gastro protective activities of MENJ“ methanolic extract of Nardostachys jatamansi rhizomes” utilizing aspirin plus pylorus ligation model should be evaluated. Nardostachys jatamansi's plant material has been gathered, dried under shade, powered and extracted with soxhlet soft methanol apparatus. The extract has been tested for flavonoids (Shinoda test), tannins (Gelatin test) and alkaloids (Mayer's and Wagner's test). The rats have been categorized into 4 groups; MENJ 100mg/kg and 200mg/kg, standard (Omeprazole 10mg/kg), control (0.3% CMC). Aspirin (200mg/kg) has been orally administered one time for five days. MENJ has been administered on 6th day for testing group as well as Omeprazole 30minute before pylorus ligation. The animals have been sacrificed after 4 hours, stomach has been excised and after that gastric juice has been gathered, centrifuged as well as biochemical studies such as ulcer and proteins index, total acidity, free acidity, gastric volume, and pH have been performed. A significant(p<0.001)rise was seen in pH (4.46±0.37) where a significant decrease was seen in total proteins (283.42±15.49), total acidity (53.42±1.26), free acidity (29.46±0.85),gastric volume (2.92±0.25),and ulcer index (1.72±0.48) after comparing with control. In contrast with Omeprazole the test dosage of 200 mg/kg has also been found to have substantial effect (p<0.01). The current research shows the involvement of flavonoids, tannins and alkaloids as a gastro protective behaviour of MENJ


: Nardostachys jatamansi, Ulcer index, Aspirin plus Pylorus ligation, Gastro protective activity.

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