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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66131

Periodontal Disease and the Antigen Presenting Cells: A review

DrHiroj Bagde,Dr. Rachita Mustilwar,DrSavita Ghom,DrPalak Upadhyay,DrNikhat Fatima,Dr Lynn Johnson


The underlying cause of periodontal disease is a complex interplay of genetic, environmental, and immunological variables, making its diagnosis and treatment difficult. Mucosal barrier dysfunction, immune system dysregulation, and persistent mucosal inflammation all contribute to this ongoing pathology. Plaque formed by germs and left on the teeth is the primary cause of periodontitis. Periodontal disease is an immunoinflammatory condition brought on by a complicated interaction between host and microbiome. The ability of the immune system to differentiate self from nonself is a defining characteristic. When an organism develops acquired immunity, it does so by producing a particular antibody response. Antigen presentation cells (APCs) serve as a connecting link between the two stages. In order to elicit a certain kind of lymphocyte response, these cells express a variety of antigenic epitopes. To further modulate the immune response, APCs may also express a variety of costimulatory molecules. The APC are the primary subject of this study because of their connection to periodontal disease.


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