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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66129

Preliminary Phytochemical Screening, In-Vitro Antioxidant Activity and Hepatoprotective Activity of Root of Ficus religiosa Linn

Pragati Pandey, Manoj Kumar Mishra, Mayank Srivastava, Pallavi Tiwari, Saurav Ghoshal

Abstract

Since ancient times, Ficus religiosais a used to treat different ailments. The folkloric use of this plant is mentioned as hepatoprotective. So, the present study was designed to assess the in-vitro antioxidant activity and the hepatoprotective activity of ethanol and aqueous extract of Ficus religiosa Linn against paracetamol induced hepatotoxicity in rats.The different extracts were evaluated for preliminary phytochemical screening and physicochemical analysis. The free radical scavenging activity of ethanol and aqueous extracts of root of Ficus religiosa Linn and ascorbic acid were measured in terms of hydrogen donating or radical scavenging ability using the stable radical DPPH. For the evaluation of the hepatoprotective activity paracetamol induced Wistar rats were treated with Silymarin (100 mg/kg, body weight) and aquesous extract of Ficus religiosa (150, 300 and 450 mg/kg, p.o.). The estimation of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin, total protein was reported

Keywords

Ficus religiosa, hepatoprotective, DPPH, anti-oxidant, Silymarin

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