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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66119

Formulation development and characterization of Powder for oral suspension containing H2 blocker drug to Combat GERD and Peptic ulcer

Megha Singhal, Pankaj Bhatt, K. Nagarajan

Abstract

In this modern era, the cases of GERD (Gastroesophageal reflux disease) and peptic ulcers are increasing rapidly, so there is an urgent need for a dosage form to target both the disorders effectively and safely. Considering this, dosage form called as POS (Powder for oral suspension) decided to formulate. Proton pump inhibitor-based drug used in this formulation has high aqueous solubility and dissolution rate in water, and it is very soluble at lower pH, i.e., increased gastric pH. Therefore, it is an ideal drug candidate in patients with peptic ulcers as gastric acid secretion is high in these patients, promoting the dissolution and bioavailability of the drug. The drugs showed compatibility with other excipients used to formulate the dosage form. The results of various trials related to this drug indicated its great therapeutic potential against the treatment of GERDand peptic ulcers. There are currently limited treatment options for the management of GERD and peptic ulcers as there is no adequate evidence to confirm this association is unavailable. In light of that, this dosage can overcome most significant gastrointestinal complications and improve overall response

Keywords

famotidine, suspension, Wet granulation, GRED, POS

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