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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66115

FORMULATION AND EVALUATION OF VORICONAZOLE LOADED AQUASOMES FOR THE TREATMENT OF FUNGAL INFECTION

Shailender Kumar, Mohd. Aquil Siddiqui, Dr. Amresh Gupta

Abstract

Aquasomes are nanoparticulate carrier systems, however, they are three-layered self-gathered structures contained a strong stage nano-crystalline focus covered with an oligomeric film to which biochemically unique particles are adsorbed paying little mind to change. Aquasomes are otherwise called "water bodies" in light of their water-like properties that protect and preserve delicate organic particles. This property of keeping up with conformational honesty as well as a serious level of surface openness is utilized to target bio-dynamic particles like antigens, protein and peptide chemicals, and genes to explicit sites. These carbohydrate-stabilized ceramic nanoparticles are known as "aquasomes," a term coined. Co-polymerization, diffusion, or adsorption of a pharmacologically active compound on the carbohydrate surface of pre-formed nanoparticles. Bio-actives are protected by aquasomes. Many other carriers are used, such as prodrugs and liposomes, in any case, these are inclined to horrendous associations between medication and the transporter. In this case, aquasomes prove to be a worthy transporter because the carbohydrate coating prevents critical denaturing interactions between the drug and the carriers.

Keywords

Fungal Infection, Nanoparticles, Aquasomes, Voriconazole.

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