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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66086

Assessment of Transthyretin Serum Level in Children Using Mobile Phones

Asmaa N. Mostafa, Doaa M. Mahrous, Hend M Moness, Reem A. Abdel Aziz


Purpose of the study:to assess whether the use of mobile phones by children would affect the Full-scale IQ and / or the concentrations of serum Transthyretin (TTR) level which is a marker of the blood brain barrier integrity. Methods:ninety children, considered as a case if they own a mobile phone with regular use in the last month, they are classified into 3 groups according to the age:group I: includes 30 children aged 4 – 6 years, group II: includes 30 children aged 6 – 13 years, and group III: includes 30 children aged 13 – 18 years. Ninety children were age matched according to the previous classification, they were considered as non-users when they are not owing mobile phone and even not using it regularly in the last month from any nearby source. Full-scale Intelligence Quotient (IQ) and serum Transthyretin levels were done to all studied groups. Results: transthyretin serum levels were significantly higher among users than non-users in total age, 13-18, and 6-13 age groups. There were significant effects of MPRF exposure on serum transthyretin levels in both total and 13-18 age groups (p value =0.003 and <0.001 respectively). MPRF exposure has also a significant effect on the Full-scale IQ in only 13-18 age group (p= 0.05). Conclusion:Raised serum Transthyretin level (which denote blood brain barrier leak) observed with longer duration of mobile phone use and associated with decrease in full-scale IQ.


mobile phones, IQ, Transthyretin, children, brain integrity.

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