DOI: 10.14704/nq.2022.20.8.NQ44913

Evaluation the prolidase activity and oxidative stress in sera ofpatients with prostatic diseases

Mohammed Ghazi Shihab Hameed, Rafah Razooq Hameed Al-Samarrai

Abstract

The study was conducted on 90 samples of people with prostate diseases(G1- include 24 samples for patients with prostate cancer-PC , G2- include 24 samples for patients with benign prostatic hyperplasia-BPH and 22 samples for patients with prostatitis G3), compared with 20 samples for healthy individuals as control group. Prostate-specific antigen-PSA, prolidase activity, glutathione-GSH, malondialdehyde_MDA and uric acid-UC were determined in sera of patients and control group.The results showed that the activity of PSA significantly elevated in G1 andG3 with no significant difference in G2, while the prolidase activity significantly decreased in G1 and G3, with significant decreased in G1,G2,and G3 for GSH and UC levels, while the level of MDA significantly elevated in three groups as compared with control group. From all the results we can conclude that the may be affected by prostate cancer and also by hyperplasia of the prostate.

Keywords

Prolidase, Prostate specific antigen, glutathione, malondialdehyde,prostatic diseases.

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