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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66010

Antidiabetic activity of flavonoid fraction of Manilkara hexandra bark in alloxon-iduced diabetic rats

Gomathi Periyasamy, Prathyusha Segu, Saraswathi Kaspa, Pranaya Pakir


The present study was undertaken to assess anti-hyperglycemic properties of flavonoid fraction of Manilkara hexandra bark (FFMH), which have been reported in Ayurveda to be useful in diabetes mellitus. Acute oral toxicity studies of FFMH were performed as per OECD-423 guidelines and antidiabetic activity was investigated on alloxoninduced diabetic rats. The levels of plasma insulin, total hemoglobin, glycosylated hemoglobin, glycogen content ad hepatic enzymes (hexokinase and glucokinase) were also estimated in normal and experimental animals. The treatment with FFMH showed significant anti hyperglycemic activity from the first week onwards. The altered levels of plasma insulin, Hemoglobin and glycosylated hemoglobin were returned to near normal range in diabetic rats treated with FFMH at different doses and the results were comparable with that of the standard glibenclamide. In diabetic control hepatic glycogen content decreased significantly by 79.54% as compared to non-diabetic control. Treatment with FFMH led to 60.70% increase in hepatic glycogen content. Treatment with FFMH increased the Glucose -6-phosphate content in the liver, indicating an overall increase in glucose influx. The content of glucokinase and hexokinase was increased by FFMH treated groups. The present study indicates that treatment of FFMH at the doses of 100mg/kg and 200mg/kg brought the parameters altered to near normal level. From this we can conclude that FFMH can be used as a potent anti diabetic agent.


Manilkara hexandra, flavonoid, antidiabetic, alloxan, glibenclamide

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