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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/nq.2022.20.11.NQ66008

Design Formulation and Evaluation ofSertaconazole Nanocrystal Loaded inAloevera Gel Using Central Composite Design

Polepalli Sindhuri, Joshna Rani Supraneni

Abstract

Sertaconazole is a BCS class II drug which is generally used as a topical agent in the treatment of various fungal infections. In order to increase the bioavailability and penetrability of the Sertaconazole nanoparticles were prepared using high pressure homogenization technique. The various parameters that involves in defining the quality of the final product are determined using Plackett-Burman design. After analyzing the factors the central composite design has been implemented to identify the various interactions among the factors selected and the best formula has been identified. The best formula has been prepared and evaluated for various parameters like particle size, morphology, zeta potential etc. After successful preparation of the nanoparticles they are lyophilized and incorporated into the nanocrystal. The Sertaconazole loaded nanocrystal was subjected to various evaluation parameters. The aloe vera nanocrystal gel has been successfully formulated by incorporating central composite design

Keywords

Sertaconazole, high pressure homogenization, Plackett-Burman design, Central composite design, aloevera-nanocrystal.

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