DOI: 10.14704/nq.2022.20.8.NQ44891

Changes in Serum Uric Acid andC-Reactive Protein in Menopausal HIV Seropositive with Osteoartritisin NAUTH, Nnewi, Nigeria

Nkiruka Rose Ukibe, Ofia Anya Kalu, Augustine ChineduIhim, OluchukwuAugustinaMeniru, Gloria EzinneUkibe, Blessing ChinyereUkibe

Abstract

Reports of increased in musculoskeletal manifestations in human immunodeficiency virus (HIV) is common since the existence of the global HIV pandemic. Various aspects of bone problems have also been associated with HIV including osteoarthritis. The aim of this study is to assess the impact of osteoarthritis on serum C -reactive protein (CRP) and uric acid among pre-menopausal and postmenopausal HIV infected women in NnamdiAzikiwe University Teaching Hospital (NAUTH), Nnewi. A total of eighty-eight (88) HIV positive women on antiretroviral therapy and control participants between the age of 18 and 65 years were randomly recruited from HIV clinic of NAUTH, Nnewi and grouped thus; Group A (25 premenopausal HIV infected women with osteoarthritis), Group B (21 premenopausal HIV infected women without osteoarthritis) both within the age range of 18-39. Group C (21 post-menopausal HIV infected with osteoarthritis), Group D (21 post-menopausal HIV infected without osteoarthritis), both within the age range of 44-63 years. Blood sample was collected using plain tubes and CRP and uric acid levels were determined using standard techniques. The study observed significantly increased CRP and uric acid levels in pre and post menopausal HIV women with osteoarthritis compared to their corresponding controls. CRP level was significantly increased in post-menopausal HIV women with osteoarthritis compared to premenopausal HIV women with osteoarthritis. No significant correlation was observed in CRP and uric acid when correlated with age and BMI. This suggests significant degree of inflammation in the affected individuals which may have been the reason for osteoarthritis

Keywords

HIV, menopause, uric acid, C-reactive protein, osteoarthritis Nigeria

Full Text

References