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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44881

ROSUVASTATIN CALCIUM LOADED NANOSTRUCTURED LIPID CARRIER FOR THE MANAGEMENT OF DIABETIC RETINOPATHY

Manodhini Elakkiya, Kousalya Selvaraj, Gowthamarajan Kuppusamy, Veera Venkata Satyanarayana Reddy Karri

Abstract

Purpose: Repurposing of Rosuvastatin Calcium as antiangiogenic molecule for the better management of diabetic retinopathy and to formulate surface modified Rosuvastatin Calcium loaded NLC to improve the permeability. To study the toxicity of the formulation and In vitro antiangiogenic activity of Rosuvastatin calcium and formulation. Methods: Rosuvastatin calcium was formulated my micro emulsion technique. Permeability of drug solution and formulation was studied using goat cornea and antiangiogenic property of drug and formulation was studied by Ex vivo. Results: Rosuvastatin calcium was more soluble in Tripalmitin, oleic acid and tween 80 (2%), Eutragit RS PO was used as surface modifier. particle size of without surface modified and with surface modified formulation was found to be 140.5nm and 151.8nm. Zeta potential was changed from -24 to +22.8 after surface modification. Entrapment efficiency of optimized F3 was found to be 88%. SEM analysis showed particle size of without surface modified and with surface modified formulation was found to be 133nm and 168nm. Formulation showed sustained release and followed peppas model in release kinetics. Permeability study was done with drug solution (8.28), uncoated formulation (25.88%) and coated formulation (34.7%). Formulation was found to be sterile FTM, NB and SCDM. IC50 value of drug and formulation was found to be 100µg/ml and 4000µg/ml. Formulation does not show toxicity at 15µg/ml. From antiangiogenic study Rosuvastatin Calcium loaded NLC showed a reduction in blood vessel growth. Conclusions: Rosuvastatin calcium showed antiangiogenic activity and % permeability is increased by surface modification of the formulation. So Rosuvastatin Calcium can be used for the better management of DR.

Keywords

Diabetic retinopathy, antiangiogenic activity, Repurposing of drug, Ocular drug delivery.

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