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Home > Archives > Volume 20, No 11 (2022) > Article

DOI: 10.14704/NQ.2022.20.11.NQ66019

CLINICOPATHOLOGICAL PROFILE OF PATIENTS PRESENTING WITHPANCYTOPENIA

Dr.Akshay Darak, Dr.Neelima Saoji, Dr.Aditya Mapari

Abstract

Background: Reduction in all 3 cellular components in peripheral blood is termed pancytopenia and this involves anaemia, neutropenia and thrombocytopenia.It is an important clinic-haematological entity and has an extensive differential diagnosis, and the optimal diagnostic approach being undefined this study was planned to evaluate the etiology, clinical profile and bone marrow morphology of pancytopenia. Methods: A single centre cross sectional, observational study was done to study clinicopathological profile of patients presenting with pancytopenia. Results: A total 100 patients of pancytopenia were evaluated most (57.0%) patients were of young age (≤ 35 years) with nearly equal number of males and female affected. Most common etiology was megaloblastic anemia (55.0%) followed by dimorphic anemia (8%) with aplastic anemia (3%) and MDS (3%) being least common. In megaloblastic anemia patients, 50.9% were pure vegetarian whereas 56.36% had history of alcoholism. Generalized weakness was most common presenting symptom (96%). Hemoglobin concentration ranged from 1.9 to 12 gm/dL with mean of 5.62±2.62. Bone marrow aspiration was hypercellular in 56.14% ,hypocellular in 31.58% and normocellular in 12.28% cases. Conclusion: Pancytopenia was common in young age population with Megaloblastic anemia secondary to alcoholism as most common cause. Congestive cardiac failure was the most complication observed among patients with pancytopenia with single case of subacute combined degeneration.

Keywords

Pancytopenia; Megaloblastic anemia; Congestive cardiac failure; Aplastic anemia; Bone marrow.

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