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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44824

REVIEW ON PANCREATIC β CELL REGENERATION: POTENTIAL DRUG THERAPY FOR DIABETES MELLITUS

Nirmal Joshi, Pooja Negi, Deepak Chandra Joshi, Mitali Danu, Jyoti Arya, Anuja Misa

Abstract

Type 1 diabetes mellitus, also known as T1DM, is the most frequent form of chronic autoimmune sickness found in young people. It is characterised by a lack of pancreatic cells, which ultimately results in hyperglycemia and an insulin shortage. It is not possible for exogenous insulin, whether it is taken orally or injected, to take the place of the insulin that is created naturally by a pancreas that is working properly. Pancreas and islet transplantation have only relatively lately been recognised as viable therapeutic options for type 1 diabetics seeking to reestablish normal levels of glucose control in their bodies. There is a major shortage of pancreases and islets derived from human organ donors, challenges related with transplantations, a high cost, and limited procedural availability. These are just some of the constraints that prevent the widespread application of these treatments. There has been some work done in order to better serve the ever-increasing population of people who are living with type 1 diabetes. Stem cell therapy has the potential to one day be utilised to treat patients suffering from Type 1 diabetes and entirely cure the condition. The advent of research into stem cell therapy for a variety of diseases has coincided with the documentation of progress made in the treatment of type 1 diabetes using stem cells. But there are still a lot of unanswered problems that need to be resolved before stem cell therapy can be considered a therapeutically feasible option for diabetes patients. In this article, we will discuss various methods for isolating insulin-producing cells (IPCs) from a wide variety of progenitor cells, as well as summarise recent breakthroughs in stem cell-based therapies for the treatment of diabetes.

Keywords

β cells, diabetes, insulin resistance,Treatment

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