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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44807

Study of Esophageal Changes in Gastroesophageal Reflux Disease in young Adult Patients

Mohamed Wagih, Hosny Abd-El-Kareem, Magdy Al-Dahshan, Eglal Kenawy, Mohamad Abdelnaser, Mohammed Ahmed


Background:According to the Montreal definition, gastroesophageal reflux disease (GERD) is “a condition in which stomach contents reflux into the esophagus, causing unpleasant complicationsand symptoms.” The purpose of this research is to learn more about the esophageal alterations related with GERD in young adults. Patients and Methods: In this study, 70 patients (36 males and 34 females)complaining of classic gastroesophageal reflux symptoms were included. In addition to 30 persons (16 males and 14 females) without esophageal symptoms and normal upper GI endoscopy results as controls,all weresubjected to a clinical assessment followed by upper GI endoscopy with multiple esophageal biopsies obtained 2-3 cm above thesquamocolumnar junction. All of them underwent 24-hour pH metry and esophageal motility studies. Results: The occurrence of erosive esophagitis was shown to have a statistically significant positive connection with male gender, age group (greater in age >30), and hiatus hernia in the current study. Esophagitis has no statistically significant link to H. pylori infection, medicine intake, coffee use, or smoking. Age, female sex, coffee use, smoking, and Hiatus hernia are all linked to frequent reflux symptoms Conclusion: There is a strong link between the global severity score obtained for all biopsies and the time spent below pH 4.0 during the whole monitoring period. In addition, the global severity score and the 24-hour composite pH score have a clear connection (DeMeester Score). As a result, histology's diagnostic significance in GERD in young adult patients should be reassessed.


Gastroesophageal reflux disease; gastrointestinal;erosive esophagitis;proton pump inhibitors

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