DOI: 10.14704/nq.2022.20.8.NQ44802

Formulation and evaluation of cefpodoxime proxetil solid dispersion incorporated in mucoadhesive microsphere

Deepak Singh Aswal, Amrita Bisht, Mohammad Sabir, Shalini Saini, Reetu Papola, Suraj Mandal

Abstract

Cefpodoxime Proxetil is a poorly water-soluble drug and prepared as solid dispersion which improved solubility and dissolution. The main purpose of this investigation was to increase solubility and dissolution rate of Cefpodoxime Proxetil by preparation of its solid dispersion with urea using solvent evaporation method. Solid dispersions of Cefpodoxime Proxetil were prepared with PEG4000 (1:1, 1:2), PEG-6000(1:1, 1:2), mannitaol (1:0.5, 1:1, 1:1.5, 1:2) and β-cyclodextrin (1:0.5, 1:1, 1:1.5, 1:2) as water-soluble carriers by solvent evaporation method, after evaluation select the best release profile solid dispersion with β-cyclodextrin is F10 (1:1) and to form the mucoadhesive microspheres with sodium alginate (1;1). These microspheres were enteric coating by CAP (10%). The drug release profile was studied and selected the best MS2 formulation. It was found that dissolution rate and dissolution parameters of drug from physical mixture as well as solid dispersion were higher than those of the intact drug. FT- IR spectra revealed no chemical incompatibility between drug and carriers

Keywords

Mucoadhesive microspheres, Cefpodoxime Proxetil, Solid dispersions, Chemical incompatibility

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