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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44790

Determination of lept in and adiponectin level in patients with End-stage renal

Sarah F.Hussein, Alaa Hussein J. Al-qaisi, TS Morad

Abstract

Chronic Renal Failure (CRF) is a term used to describe an irreversible decline in renal function that often occurs over a number of years. In many situations, an initial insult to the kidney function leads to additional nephron loss and the requirement for dialysis or kidney transplantation End stage renal disease(ESRD) is the term used to describe this ailment. A number of metabolic, vascular, and inflammatory illnesses are caused by adipokines. In order to determine whether certain associated biomarkers can aid in the diagnosis of CRF patients, this study compares the levels of inflammatory adipocytokines (leptin and adiponectine), as well as their ratios, in ESRD patients and healthy controls. Methods: In all, 70 ESRD patients30 men and 40 femaleswith ages ranging from (30 to 55) years old and 30 controls 13 males and 17 females with ages ranging from (25 to 60) years old were included in the study. All participants' biochemical characteristics, demographic information, and serum leptin and adiponectin concentrations were examined. Results: According to our research, people with chronic renal failure had significantly greater serum levels of leptin and adiponectin than did healthy controls.leptin and adiponectin had positive correlation with urea and creatinine. Conclusion: We found differences in adipokine levels that might be used to detect chronic renal failure

Keywords

Analyze of serum levels of Leptin and Adiponectin inend-stage renal disease (ESRD)and Healthy individuals.

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