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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44775

Assessment of Serum Connective Tissue Growth Factor Levels in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease

Ahmed Fawzy Fahmy Mahjoub, Beshier Abdallah Hassan, Hanan Samir Ahmed, Sherief Mohammed El-Gebaly


Background:Pulmonary arterial hypertension (PAH) is a severe progressive disease with high mortality and morbidity, ultimately leading to elevated pulmonary vascular resistance, right sided heart failure and death. there are several observations, demonstrating that Connective tissue growth factor (CTGF) is intimately correlated with pulmonary vascular remodeling. Aim of work: To investigate serum connective tissue growth factor level and its relation to pediatric pulmonary arterial hypertension associated with congenital heart disease in Zagazig University Hospitals. Materials and Methods: This case-control study was carried out at in Zagazig University Hospitals from July 2019 to Jan 2020. The subjects were divided into two groups. Group I [cases] included 21 patients diagnosed as pulmonary hypertension associated with congenital heart disease and Group II [control] included 21 healthy infant and children. All individuals were subjected to full history taking, clinical examination, echocardiograph and laboratory investigations including plasma CTGFs levels. Results: Serum CTGF levels were significantly higher in Group I (1774.6 ± 500.8pmol/L) than in control group. Conclusion: Serum CTGF levels were significantly elevated in children with PAH-CHD inversely correlated with oxygen saturation


Congenital, Heart, Pulmonary hypertension, Connective tissue growth factor

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